Use of handheld reflectance confocal microscopy for in vivo diagnosis of solitary facial papules: A case series Journal Article


Authors: Fraga-Braghiroli, N. A.; Stephens, A.; Grossman, D.; Rabinovitz, H.; Castro, R. P. R.; Scope, A.
Article Title: Use of handheld reflectance confocal microscopy for in vivo diagnosis of solitary facial papules: A case series
Abstract: Background: Reflectance Confocal Microscopy (RCM) can be useful for evaluation of solitary pink papules that are suspicious for skin cancer. RCM has been challenging to apply to curvy facial areas because of the need for attaining full contact between the skin and RCM probe. A smaller diameter handheld RCM probe has been recently introduced to clinical practice. Objective: To describe the utility of RCM handheld probe as a bedside adjunct for clinical diagnosis of solitary facial papules. Methods: This is a retrospective descriptive case series of six patients presented with a diagnostically equivocal solitary facial papule. All lesions reported were evaluated and imaged clinically, dermoscopically and with handheld RCM, followed by biopsy for histopathological analysis. Results: The series included biopsy-proven basal cell carcinomas (BCCs) (n = 2), squamous cell carcinoma (n = 1), sebaceous hyperplasia (n = 1), desmoplastic trichoepithelioma (n = 1) and compound nevus (n = 1). Handheld RCM was easy to apply to the curved facial surfaces and allowed for reaching a correct bedside diagnosis. Conclusion: For clinically and dermoscopically equivocal small papules on curved facial surfaces, handheld RCM may be particularly helpful in differentiating benign lesions from skin cancer. © 2013 European Academy of Dermatology and Venereology.
Keywords: adult; clinical article; aged; middle aged; histopathology; squamous cell carcinoma; diagnostic procedure; reflectance confocal microscopy; basal cell carcinoma; confocal microscopy; skin biopsy; nevus; differential diagnosis; in vivo study; hyperplasia; papule; desmoplastic trichoepithelioma; trichoepithelioma; human; male; female; priority journal; article; confocal microscope; sebaceous hyperplasia
Journal Title: Journal of the European Academy of Dermatology and Venereology
Volume: 28
Issue: 7
ISSN: 0926-9959
Publisher: Wiley Blackwell  
Date Published: 2014-07-01
Start Page: 933
End Page: 942
Language: English
DOI: 10.1111/jdv.12218
PROVIDER: scopus
PUBMED: 23889040
DOI/URL:
Notes: Export Date: 2 September 2014 -- CODEN: JEAVE -- Source: Scopus
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