Pilot study of oral valganciclovir therapy in patients with classic Kaposi sarcoma Journal Article
| Authors: | Krown, S. E.; Dittmer, D. P.; Cesarman, E. |
| Article Title: | Pilot study of oral valganciclovir therapy in patients with classic Kaposi sarcoma |
| Abstract: | We conducted a clinical trial of oral valganciclovir, a drug with in vitro activity against Kaposi sarcoma (KS) - associated herpesvirus (KSHV), in classic KS. Five human immunodeficiency virus - seronegative participants received valganciclovir for up to six 4-week cycles at doses used for cytomegalovirus infection. None of the study subjects showed an objective response; KS progressed in 4 subjects after 1-4 cycles and remained stable in 1 subject after 6 cycles. KS biopsies showed minimal lytic KSHV antigen and gene expression at baseline and no treatment-associated changes. Although valganciclovir was not active against KS in this setting, other appropriately targeted anti-herpesviral strategies may prove to be more effective. © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. |
| Keywords: | adult; clinical article; human tissue; aged; unclassified drug; clinical trial; drug tolerability; drug dose reduction; drug efficacy; drug safety; side effect; multiple cycle treatment; gene expression; tumor biopsy; kidney function; pilot study; interleukin 6; virus antigen; kaposi sarcoma; tumor growth; human herpesvirus 8; valganciclovir; latency associated nuclear antigen; kaposi sarcoma associated herpesvirus antigen; open reading frame 59 protein; open reading frame k8.1 protein |
| Journal Title: | Journal of Infectious Diseases |
| Volume: | 203 |
| Issue: | 8 |
| ISSN: | 0022-1899 |
| Publisher: | Oxford University Press |
| Date Published: | 2011-04-15 |
| Start Page: | 1082 |
| End Page: | 1086 |
| Language: | English |
| DOI: | 10.1093/infdis/jiq177 |
| PROVIDER: | scopus |
| PUBMED: | 21450998 |
| PMCID: | PMC6767870 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 23 June 2011" - "CODEN: JIDIA" - "Source: Scopus" |
