Th17 Cells Express Interleukin-10 Receptor and Are Controlled by Foxp3- and Foxp3+ Regulatory CD4+ T Cells in an Interleukin-10-Dependent Manner Journal Article
| Authors: | Huber, S.; Gagliani, N.; Esplugues, E.; O'Connor, W.; Huber, F.; Chaudhry, A.; Kamanaka, M.; Kobayashi, Y.; Booth, C.; Rudensky, A.; Roncarolo, M.; Battaglia, M.; Flavell, R. |
| Article Title: | Th17 Cells Express Interleukin-10 Receptor and Are Controlled by Foxp3- and Foxp3+ Regulatory CD4+ T Cells in an Interleukin-10-Dependent Manner |
| Abstract: | T helper 17 (Th17) cells are important for host defense against extracellular microorganisms. However, they are also implicated in autoimmune and chronic inflammatory diseases, and as such need to be tightly regulated. The mechanisms that directly control committed pathogenic Th17 cells in vivo remain unclear. We showed here that IL-17A-producing CD4+ T cells expressed interleukin-10 receptor α (IL-10Rα) in vivo. Importantly, T cell-specific blockade of IL-10 signaling led to a selective increase of IL-17A+IFN-γ- (Th17) and IL-17A+IFN-γ+ (Th17+Th1) CD4+ T cells during intestinal inflammation in the small intestine. CD4+Foxp3- IL-10-producing (Tr1) cells and CD4+Foxp3+ regulatory (Treg) cells were able to control Th17 and Th17+Th1 cells in an IL-10-dependent manner in vivo. Lastly, IL-10 treatment of mice with established colitis decreased Th17 and Th17+Th1 cell frequencies via direct signaling in T cells. Thus, IL-10 signaling directly suppresses Th17 and Th17+Th1 cells. © 2011 Elsevier Inc. |
| Keywords: | signal transduction; controlled study; protein expression; nonhuman; transcription factor foxp3; animal cell; mouse; animal tissue; interleukin 10; animal experiment; animal model; in vivo study; regulatory t lymphocyte; regulatory mechanism; gamma interferon; cd4+ t lymphocyte; enteritis; interleukin 17; th17 cell; th1 cell; interleukin 10 receptor alpha |
| Journal Title: | Immunity |
| Volume: | 34 |
| Issue: | 4 |
| ISSN: | 1074-7613 |
| Publisher: | Cell Press |
| Date Published: | 2011-04-22 |
| Start Page: | 554 |
| End Page: | 565 |
| Language: | English |
| DOI: | 10.1016/j.immuni.2011.01.020 |
| PROVIDER: | scopus |
| PMCID: | PMC3113617 |
| PUBMED: | 21511184 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 23 June 2011" - "CODEN: IUNIE" - "Source: Scopus" |
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