Bevacizumab in metastatic breast cancer: When may it be used? Journal Article
| Authors: | Goldfarb, S. B.; Hudis, C.; Dickler, M. N. |
| Article Title: | Bevacizumab in metastatic breast cancer: When may it be used? |
| Abstract: | Tumor angiogenesis, which is necessary for breast cancer growth, invasion and metastases, is regulated by pro-angiogenic factors such as vascular endothelial growth factor (VEGF). Bevacizumab is a recombinant humanized monoclonal antibody that targets VEGF. The addition of bevacizumab to chemotherapy has improved progression-free survival in the first- and second-line treatment of patients with advanced-stage breast cancer. In this article we review the clinical trials testing the utility of bevacizumab for the treatment of metastatic disease. © The Author(s), 2011. |
| Keywords: | cancer chemotherapy; cancer survival; fatigue; review; bevacizumab; placebo; advanced cancer; diarrhea; drug dose reduction; drug safety; drug withdrawal; hypertension; monotherapy; nonhuman; capecitabine; gemcitabine; paclitaxel; low drug dose; metastasis; progression free survival; multiple cycle treatment; breast cancer; bleeding; myalgia; docetaxel; arthralgia; asthenia; cancer hormone therapy; drug dose escalation; dyspnea; loading drug dose; vascular endothelial growth factor; brain metastasis; tamoxifen; nausea and vomiting; headache; letrozole; anastrozole; navelbine; anthracycline; hand foot syndrome; estradiol; brain ischemia; proteinuria; nephrotic syndrome; fulvestrant; hypertension encephalopathy; progression-free survival; randomized controlled trial (topic); mucosal bleeding |
| Journal Title: | Therapeutic Advances in Medical Oncology |
| Volume: | 3 |
| Issue: | 2 |
| ISSN: | 1758-8340 |
| Publisher: | Sage Publications Ltd. |
| Date Published: | 2011-03-01 |
| Start Page: | 85 |
| End Page: | 93 |
| Language: | English |
| DOI: | 10.1177/1758834010397627 |
| PROVIDER: | scopus |
| PMCID: | PMC3126041 |
| PUBMED: | 21789158 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 23 June 2011" - "Source: Scopus" |
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