Bevacizumab in the treatment of metastatic breast cancer Journal Article
| Author: | Traina, T. A. |
| Article Title: | Bevacizumab in the treatment of metastatic breast cancer |
| Abstract: | Increased levels of vascular endothelial growth factor (VEGF) have been associated with a poor prognosis for patients with breast cancer. In addition to its prognostic role, VEGF is also a validated target in the treatment of this disease. Bevacizumab, an anti-VEGF antibody, has demonstrated significant clinical benefit in several solid tumors, including breast cancer. Its use in combination with either paclitaxel or docetaxel has prolonged progression-free survival and increased response rates in the first-line treatment of patients with metastatic, HER2-negative breast cancer. In this paper, the clinical trials establishing bevacizumab use for the treatment of breast cancer are reviewed. |
| Keywords: | vasculotropin; cancer survival; treatment outcome; disease-free survival; vascular endothelial growth factor a; clinical trial; drug tolerability; review; bevacizumab; doxorubicin; placebo; advanced cancer; drug efficacy; drug safety; drug withdrawal; hypertension; monotherapy; capecitabine; gemcitabine; paclitaxel; adjuvant therapy; evidence-based medicine; carboplatin; progression free survival; multiple cycle treatment; breast cancer; protein targeting; bleeding; nausea; vomiting; antineoplastic combined chemotherapy protocols; myalgia; cyclophosphamide; breast neoplasms; time factors; docetaxel; asthenia; drug dose escalation; dyspnea; febrile neutropenia; cancer inhibition; drug induced headache; survival time; antibodies, monoclonal; vein thrombosis; thrombosis; drug response; vorinostat; tamoxifen; letrozole; optimal drug dose; metastasis potential; trastuzumab; anastrozole; navelbine; antigen binding; angiogenesis inhibitors; tumor vascularization; brain ischemia; antiangiogenic activity; congestive heart failure; proteinuria; lapatinib; artery thrombosis; nephrotic syndrome; cardiomyopathy; fulvestrant; pertuzumab; hypertension encephalopathy |
| Journal Title: | Oncology (Norwalk) |
| Volume: | 23 |
| Issue: | 4 |
| ISSN: | 0890-9091 |
| Publisher: | C M P Medica LLC * The Oncology Group |
| Date Published: | 2009-04-15 |
| Start Page: | 327 |
| End Page: | 332 |
| Language: | English |
| PUBMED: | 19476261 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "CODEN: OCLGE" - "Source: Scopus" |
