Serum immunoglobulin e and risk of pancreatic cancer in the prostate, lung, colorectal, and ovarian cancer screening trial Journal Article


Authors: Olson, S. H.; Hsu, M.; Wiemels, J. L.; Bracci, P. M.; Zhou, M.; Patoka, J.; Reisacher, W. R.; Wang, J.; Kurtz, R. C.; Silverman, D. T.; Stolzenberg-Solomon, R. Z.
Article Title: Serum immunoglobulin e and risk of pancreatic cancer in the prostate, lung, colorectal, and ovarian cancer screening trial
Abstract: Epidemiologic studies have consistently found that self-reported allergies are associated with reduced risk of pancreatic cancer. Our aim was to prospectively assess the relationship between serum immunoglobulin E (IgE), a marker of allergy, and risk. This nested case-control study within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) included subjects enrolled in 1994 to 2001 and followed through 2010. There were 283 cases of pancreatic cancer and 544 controls matched on age, gender, race, and calendar date of blood draw. Using the ImmunoCAP system, we measured total IgE (normal, borderline, elevated), IgE to respiratory allergens, and IgE to food allergens (negative or positive) in serum collected at baseline. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using conditional logistic regression. We assessed interactions with age, gender, smoking, body mass index, and time between randomization and case diagnosis. Overall, there was no association between the IgE measures and risk. We found a statistically significant interaction by baseline age: in those aged ±65 years, elevated risks were observed for borderline total IgE (OR, 1.43; 95% CI, 0.88-2.32) and elevated total IgE (OR, 1.98; 95% CI, 1.16-3.37) and positive IgE to food allergens (OR, 2.83; 95% CI, 1.29-6.20); among participants <65 years, ORs were <1. Other interactions were not statistically significant. The reduced risk of pancreatic cancer associated with self-reported allergies is not reflected in serum IgE. © 2014 American Association for Cancer Research.
Journal Title: Cancer Epidemiology Biomarkers and Prevention
Volume: 23
Issue: 7
ISSN: 1055-9965
Publisher: American Association for Cancer Research  
Date Published: 2014-07-01
Start Page: 1414
End Page: 1420
Language: English
DOI: 10.1158/1055-9965.epi-13-1359
PROVIDER: scopus
PUBMED: 24718282
PMCID: PMC4120187
DOI/URL:
Notes: Export Date: 1 August 2014 -- CODEN: CEBPE -- Source: Scopus
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  1. Meier Hsu
    169 Hsu
  2. Sara H Olson
    234 Olson
  3. Robert C Kurtz
    196 Kurtz