Environment-responsive nanophores for therapy and treatment monitoring via molecular MRI quenching Journal Article

   

Authors:	Kaittanis, C.; Shaffer, T. M.; Ogirala, A.; Santra, S.; Perez, J. M.; Chiosis, G.; Li, Y.; Josephson, L.; Grimm, J.
Article Title:	Environment-responsive nanophores for therapy and treatment monitoring via molecular MRI quenching
Abstract:	The effective delivery of therapeutics to disease sites significantly contributes to drug efficacy, toxicity and clearance. Here we demonstrate that clinically approved iron oxide nanoparticles (Ferumoxytol) can be utilized to carry one or multiple drugs. These so called 'nanophores' retain their cargo within their polymeric coating through weak electrostatic interactions and release it in slightly acidic conditions (pH 6.8 and below). The loading of drugs increases the nanophores' transverse T2 and longitudinal T1 nuclear magnetic resonance (NMR) proton relaxation times, which is proportional to amount of carried cargo. Chemotherapy with translational nanophores is more effective than the free drug in vitro and in vivo, without subjecting the drugs or the carrier nanoparticle to any chemical modification. Evaluation of cargo incorporation and payload levels in vitro and in vivo can be assessed via benchtop magnetic relaxometers, common NMR instruments or magnetic resonance imaging scanners. © 2014 Macmillan Publishers Limited.
Keywords:	controlled study; unclassified drug; human cell; nonhuman; chemotherapy; nuclear magnetic resonance imaging; monitoring; mouse; animal experiment; ph; in vivo study; in vitro study; molecular analysis; nanoparticle; toxicity; static electricity; nuclear magnetic resonance; drug delivery system; proton nuclear magnetic resonance; chemical modification; drug release; drug; ferumoxytol; relaxation time; human; article; nanophore; particulate matter
Journal Title:	Nature Communications
Volume:	5
ISSN:	2041-1723
Publisher:	Nature Publishing Group
Date Published:	2014-03-04
Start Page:	3384
Language:	English
DOI:	10.1038/ncomms4384
PROVIDER:	scopus
PMCID:	PMC4108301
PUBMED:	24594970
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84895833422&partnerID=40&md5=6ab6e5b5c21a75a2a07f70662cd35748
Notes:	Correction issued, see DOI: 10.1038/s41467-019-09887-3 -- Export Date: 1 August 2014 -- Source: Scopus