Nanocrystal core high-density lipoproteins: A multimodality contrast agent platform Journal Article
| Authors: | Cormode, D. P.; Skajaa, T.; Van Schooneveld, M. M.; Koole, R.; Jarzyna, P.; Lobatto, M. E.; Calcagno, C.; Barazza, A.; Gordon, R. E.; Zanzonico, P.; Fisher, E. A.; Fayad, Z. A.; Mulder, W. J. M. |
| Article Title: | Nanocrystal core high-density lipoproteins: A multimodality contrast agent platform |
| Abstract: | High density lipoprotein (HDL) is an important natural nanoparticle that may be modified for biomedical imaging purposes. Here we developed a novel technique to create unique multimodality HDL mimicking nanoparticles by incorporation of gold, iron oxide, or quantum dot nanocrystals for computed tomography, magnetic resonance, and fluorescence imaging, respectively. By including additional labels in the corona of the particles, they were made multifunctional. The characteristics of these nanoparticles, as well as their in vitro and in vivo behavior, revealed that they closely mimic native HDL. © 2008 American Chemical Society. |
| Keywords: | mouse; animal; animals; mice; cell line; chemistry; computerized tomography; diagnostic radiography; tomography; nanoparticles; in-vivo; contrast medium; contrast media; macrophage; macrophages; in-vitro; ultrastructure; contrast agents; fluorescence imaging; quantum dots; semiconductor quantum dots; iron oxides; metal nanoparticle; metal nanoparticles; microscopy, electron, transmission; transmission electron microscopy; gold; nanocrystals; high density lipoprotein; biomedical imaging; computed tomographies; high-density lipoproteins; multi modalities; novel techniques; lipoproteins, hdl |
| Journal Title: | Nano Letters |
| Volume: | 8 |
| Issue: | 11 |
| ISSN: | 1530-6984 |
| Publisher: | American Chemical Society |
| Date Published: | 2008-11-01 |
| Start Page: | 3715 |
| End Page: | 3723 |
| Language: | English |
| DOI: | 10.1021/nl801958b |
| PUBMED: | 18939808 |
| PROVIDER: | scopus |
| PMCID: | PMC2629801 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 56" - "Export Date: 17 November 2011" - "Source: Scopus" |
