Genomic imbalance defines three prognostic groups for risk stratification of patients with chronic lymphocytic leukemia Journal Article


Authors: Houldsworth, J.; Guttapalli, A.; Thodima, V.; Yan, X. J.; Mendiratta, G.; Zielonka, T.; Nanjangud, G.; Chen, W.; Patil, S.; Mato, A.; Brown, J. R.; Rai, K.; Chiorazzi, N.; Chaganti, R. S. K.
Article Title: Genomic imbalance defines three prognostic groups for risk stratification of patients with chronic lymphocytic leukemia
Abstract: Array comparative genomic hybridization (aCGH) has yet to be fully leveraged in a prognostic setting in chronic lymphocytic leukemia (CLL). Genomic imbalance was assessed in 288 CLL specimens using a targeted array. Based on 20 aberrations in a hierarchical manner, all 228 treatment-naive specimens were classified into a group with poor outcome (20.6%) exhibiting at least one aberration that was univariately associated with adverse outcome (gain: 2p, 3q, 8q, 17q, loss: 7q, 8p, 11q, 17p, 18p), good outcome (32.5%) showing 13q14 loss without any of the other 10 aberrations (gain: 1p, 7p, 12, 18p, 18q, 19, loss: 4p, 5p, 6q, 7p) or intermediate outcome (remainder). The three groups were significantly separated with respect to time to first treatment and overall survival ( p < 0.001), and validation of the stratification scheme was performed in two independent datasets. Gain of 3q and 8q, and 17p loss were determined to be independent unfavorable prognostic biomarkers. TP53 , NOTCH1 and SF3B1 mutations correlated with the presence of one poor outcome aCGH marker, at a considerably higher frequency than when only considering poor risk aberrations routinely detected by fluorescence in situ hybridization (FISH). These data support genomic imbalance evaluation in CLL by aCGH to assist in risk stratification. © 2014 Informa UK, Ltd.
Keywords: molecular genetics; prognostication; lymphoid leukemia
Journal Title: Leukemia and Lymphoma
Volume: 55
Issue: 4
ISSN: 1042-8194
Publisher: Taylor & Francis Group  
Date Published: 2014-04-01
Start Page: 920
End Page: 928
Language: English
DOI: 10.3109/10428194.2013.845882
PROVIDER: scopus
PUBMED: 24047479
DOI/URL:
Notes: Export Date: 1 August 2014 -- CODEN: LELYE -- Source: Scopus
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MSK Authors
  1. Sujata Patil
    383 Patil
  2. Raju S K Chaganti
    261 Chaganti