Human papillomavirus and Epstein-Barr virus in nasopharyngeal carcinoma in a low-incidence population Journal Article
| Authors: | Dogan, S.; Hedberg, M. L.; Ferris, R. L.; Rath, T. J.; Assaad, A. M.; Chiosea, S. I. |
| Article Title: | Human papillomavirus and Epstein-Barr virus in nasopharyngeal carcinoma in a low-incidence population |
| Abstract: | Background The significance of human papillomavirus (HPV) in nasopharyngeal carcinomas (NPCs) in a low-incidence population remains unknown. Methods Samples from 90 patients with NPC (years, 1957-2012) were analyzed for Epstein-Barr virus (EBV). Clinical data, EBV, HPV, and p16 status were correlated with overall survival (OS; 63 cases; years, 1981-2012). Results Of 9 HPV-positive cases, 3 extended from extra-nasopharyngeal sites. Nasopharyngeal origin was confirmed in 6 cases. HPV-positive NPC had OS similar to EBV-positive NPC (85 vs 141 months; p >.05). The OS of patients with EBV/HPV-negative NPC was worse (34 months; p =.004). Nonkeratinizing histology was associated with better outcome than keratinizing (115 vs 25 months; p =.001). Over the last several decades, the proportion of keratinizing NPC decreased from 34.5% to 14.3% (p =.026). Conclusion The etiologic role of HPV in NPC is confirmed. The favorable prognostic significance of HPV positivity is similar to that of EBV positivity. © 2013 Wiley Periodicals, Inc. |
| Keywords: | adult; cancer survival; controlled study; human tissue; aged; middle aged; young adult; major clinical study; overall survival; histopathology; cancer incidence; disease association; protein p16; retrospective study; nasopharynx carcinoma; nasopharyngeal carcinoma; epstein barr virus; wart virus; human papillomavirus; keratinization; cancer prognosis; epstein-barr virus; low risk population; very elderly; human; male; female; priority journal; article; virus etiology |
| Journal Title: | Head & Neck |
| Volume: | 36 |
| Issue: | 4 |
| ISSN: | 1043-3074 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 2014-01-01 |
| Start Page: | 511 |
| End Page: | 516 |
| Language: | English |
| DOI: | 10.1002/hed.23318 |
| PROVIDER: | scopus |
| PUBMED: | 23780921 |
| PMCID: | PMC4656191 |
| DOI/URL: | |
| Notes: | Export Date: 1 August 2014 -- CODEN: HEANE -- Source: Scopus |
