Prognostic significance of human papillomavirus and Epstein-Bar virus in nasopharyngeal carcinoma Journal Article
| Authors: | Verma, N.; Patel, S.; Osborn, V.; McBride, S.; Riaz, N.; Lee, A.; Katabi, N.; Sherman, E.; Lee, N. Y.; Tsai, C. J. |
| Article Title: | Prognostic significance of human papillomavirus and Epstein-Bar virus in nasopharyngeal carcinoma |
| Abstract: | Background: The clinical significance of Epstein-Barr virus (EBV) and human papillomavirus (HPV) infection in nasopharyngeal carcinoma (NPC) is unclear. Methods: Three hundred and forty three patients with NPC diagnosed between 1998 and 2017 and treated at our institution were included. Chi-square was used to identify characteristics associated with viral status. Kaplan-Meier methods were used to estimate overall survival (OS) and Cox proportional regression was used to identify prognostic factors. Results: Patients with HPV-associated NPC were more likely to have a positive smoking history and to present at a higher T classification. At a median follow-up time of 59.9 months (range: 0.1-222.4 months), there were no differences in OS (P =.198), time to local failure (LF, P =.403), or time to distant metastasis (DM, P =.849) between the viral subgroups. Older age (hazard ratio [HR]: 2.242, 95% confidence interval [CI] 1.374-3.659, P =.001) and higher overall stage (HR: 2.047, 95% CI 1.235-3.391, P =.005) were prognostic for worse OS. Conclusion: In our population, viral status was not prognostic for OS, LF, or DM. © 2020 Wiley Periodicals, Inc. |
| Keywords: | adolescent; adult; cancer chemotherapy; child; controlled study; aged; major clinical study; overall survival; intensity modulated radiation therapy; cancer risk; follow up; antineoplastic agent; cancer diagnosis; progression free survival; prevalence; smoking; practice guideline; retrospective study; distant metastasis; karnofsky performance status; nasopharynx carcinoma; cancer classification; nasopharyngeal carcinoma; medical history; human papillomavirus; papillomavirus infection; hpv; epstein barr virus infection; ebv; cancer prognosis; local failure free survival; human; male; female; priority journal; article; epstein-bar virus; regional failure free survival |
| Journal Title: | Head & Neck |
| Volume: | 42 |
| Issue: | 9 |
| ISSN: | 1043-3074 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 2020-09-01 |
| Start Page: | 2364 |
| End Page: | 2374 |
| Language: | English |
| DOI: | 10.1002/hed.26245 |
| PUBMED: | 32415906 |
| PROVIDER: | scopus |
| PMCID: | PMC10291490 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 September 2020 -- Source: Scopus |
