How I treat: The selection and acquisition of unrelated cord blood grafts Journal Article

   


Authors: Barker, J. N.; Byam, C.; Scaradavou, A.
Article Title: How I treat: The selection and acquisition of unrelated cord blood grafts
Abstract: Use of unrelated donor cord blood (CB) as an alternative stem cell source is increasing, and yet there is little information to guide transplant centers in the unique aspects of the search and selection of CB grafts. There is no mechanism to easily access the global inventory of CB units, nor is the product information provided by all banks standardized. To address these challenges, this manuscript reviews the logistics of the search, selection process, and acquisition of CB grafts as practiced by our center. Topics include who should be considered for a CB search, how to access the global CB inventory, and how to balance total nucleated cell dose and human leukocyte antigen match in unit selection. We discuss aspects of unit quality and other graft characteristics (processing methods, unit age, availability of attached segments, infectious disease, and hemoglobinopathy screening) to be considered.We incorporate these considerations into a unit selection algorithm, including how to select double-unit grafts. We also describe how we plan for unit shipment and the role of backup grafts. This review aims to provide a framework for CB unit selection and help transplantation centers perform efficient CB searches. © 2011 by The American Society of Hematology.
Keywords: review; cord blood stem cell transplantation; fetal blood; blood banks; tissue donors; processing; screening; umbilical cord blood; hla antigen; histocompatibility testing; hemoglobinopathy; blood donor
Journal Title: Blood
Volume: 117
Issue: 8
ISSN: 0006-4971
Publisher: American Society of Hematology  
Date Published: 2011-02-24
Start Page: 2332
End Page: 2339
Language: English
DOI: 10.1182/blood-2010-04-280966
PUBMED: 21149636
PROVIDER: scopus
PMCID: PMC3062405
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-79952171355&partnerID=40&md5=5322f6f7a6324394c3d13312abb44c1c
Notes: --- - "Export Date: 23 June 2011" - "CODEN: BLOOA" - "Source: Scopus"
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MSK Authors
  1. Andromachi Scaradavou
    243 Scaradavou
  2. Juliet N Barker
    335 Barker
  3. Courtney Elizabeth Jorgensen
    24 Jorgensen
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