Guidelines for cord blood unit selection Review


Authors: Politikos, I.; Davis, E.; Nhaissi, M.; Wagner, J. E.; Brunstein, C. G.; Cohen, S.; Shpall, E. J.; Milano, F.; Scaradavou, A.; Barker, J. N.; on behalf of the American Society for Transplantation and Cellular Therapy Cord Blood Special Interest Group
Review Title: Guidelines for cord blood unit selection
Abstract: Optimal cord blood (CB) unit selection is critical to maximize the likelihood of successful engraftment and survival after CB transplantation (CBT). However, unit selection can be complex because multiple characteristics must be considered including unit cell dose, donor-recipient human leukocyte antigen (HLA) match, and unit quality. This review provides evidence-based and experience-based comprehensive guidelines for CB unit selection. Topics addressed include the use of both the TNC and the CD34+ cell dose, as well as the CD34+ cell to TNC content ratio to evaluate unit progenitor cell content and engraftment potential, the acceptable TNC and CD34+ cell dose criteria that define an adequate single-unit graft, and the indication and acceptable cell dose criteria for double-unit grafts. The acceptable criteria for 6-loci (HLA-A, -B antigen, -DRB1 allele) and 8-allele (HLA-A, -B, -C, -DRB1) donor-recipient HLA match, the evaluation of patients with donor-specific HLA antibodies, and the multiple determinants of unit quality are also reviewed in detail. Finally, a practical step-by-step guide to CB searches and the principles that guide ultimate graft selection are outlined. © 2020 American Society for Transplantation and Cellular Therapy
Keywords: practice guideline; hla match; cb unit selection; cd34+ cell dose; tnc dose
Journal Title: Biology of Blood and Marrow Transplantation
Volume: 26
Issue: 12
ISSN: 1083-8791
Publisher: Elsevier Inc.  
Date Published: 2020-12-01
Start Page: 2190
End Page: 2196
Language: English
DOI: 10.1016/j.bbmt.2020.07.030
PUBMED: 32736011
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 4 January 2021 -- Source: Scopus
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MSK Authors
  1. Juliet N Barker
    296 Barker
  2. Eric Nelson Davis
    16 Davis