Influence of infused cell dose and HLA match on engraftment after double-unit cord blood allografts Journal Article
| Authors: | Avery, S.; Shi, W.; Lubin, M.; Gonzales, A. M.; Heller, G.; Castro-Malaspina, H.; Giralt, S.; Kernan, N. A.; Scaradavou, A.; Barker, J. N. |
| Article Title: | Influence of infused cell dose and HLA match on engraftment after double-unit cord blood allografts |
| Abstract: | The influence of cell dose and human leukocyte antigen (HLA) match on double-unit cord blood (CB) engraftment is not established. Therefore, we analyzed the impact of cell dose and high-resolution HLA match on neutrophil engraftment in 84 double-unit CB transplant recipients. The 94% sustained engraftment rate was accounted for by 1 unit in nearly all patients. Higher CD3+ cell doses (P = .04) and percentage of CD34+ cell viability (P = .008) were associated with unit dominance. After myeloablative conditioning, higher dominant unit total nucleated cell (TNC), CD34+ cell, and colony-forming unit doses were associated with higher sustained engraftment and faster neutrophil recovery (P = .07, P = .0008, and P < .0001, respectively). Total infused TNC (P = .0007) and CD3+ cell doses (P = .001) also significantly influenced engraftment. At high-resolution extensive donor-recipient HLA disparity was frequent, but had no influence on engraftment (P = .66), or unit dominance (P = .13). Although the unit-unit HLA match also did not affect sustained engraftment (P = 1.0), recipients of units closely (7-10 to 10-10) HLA-matched to each other were more likely to demonstrate initial engraftment of both units (P < .0001). Our findings have important implications for unit selection and provide further insight into double-unit biology. © 2011 by The American Society of Hematology. |
| Keywords: | adolescent; adult; child; preschool child; school child; aged; major clinical study; cell viability; cd34 antigen; engraftment; graft failure; hla matching; myeloablative conditioning; neutrophil; infant; umbilical cord blood; cd3+ t lymphocyte; colony forming unit |
| Journal Title: | Blood |
| Volume: | 117 |
| Issue: | 12 |
| ISSN: | 0006-4971 |
| Publisher: | American Society of Hematology |
| Date Published: | 2011-03-24 |
| Start Page: | 3277 |
| End Page: | 3285 |
| Language: | English |
| DOI: | 10.1182/blood-2010-08-300491 |
| PROVIDER: | scopus |
| PMCID: | PMC3069669 |
| PUBMED: | 21149633 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 23 June 2011" - "CODEN: BLOOA" - "Source: Scopus" |
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MSK Authors
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512Kernan -
399Heller -
121Shi -
1050Giralt -
243Scaradavou -
335Barker -
6Avery -
333Castro-Malaspina -
79Lubin -
43
Gonzales
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