Will the new cytogenetics replace the old cytogenetics? Journal Article
| Authors: | Salman, M.; Jhanwar, S. C.; Ostrer, H. |
| Article Title: | Will the new cytogenetics replace the old cytogenetics? |
| Abstract: | With the advent of array-based comparative genomic hybridization technology, the analog cytogenetic analysis that has been used for the past 100 years could be replaced by the quantitative, microarray-based molecular analysis. Major advantages of the new array-based cytogenetic technologies are the high resolution and the high throughput. This technology is the first to offer an autonomous whole-chromosome analysis in one hybridization reaction for the detection of submicroscopic gains/losses. However, as with any new technology, it needs to be validated with regard to its performance in various applications (e.g. clinical genetic testing and cancer applications), comparative cost, and the data interpretation. Copyright © Blackwell Munksgaard 2004. |
| Keywords: | controlled study; single nucleotide polymorphism; validation process; genetic analysis; cytogenetics; high throughput screening; data analysis; short survey; genome; dna microarray; microarray; chromosome aberrations; nucleic acid hybridization; genetic screening; chromosome analysis; chromosome loss; comparative genomic hybridization; cost; cancer; humans; human; priority journal |
| Journal Title: | Clinical Genetics |
| Volume: | 66 |
| Issue: | 4 |
| ISSN: | 0009-9163 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2004-10-01 |
| Start Page: | 265 |
| End Page: | 275 |
| Language: | English |
| DOI: | 10.1111/j.1399-0004.2004.00316.x |
| PUBMED: | 15355426 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Cited By (since 1996):29 -- Export Date: 16 June 2014 -- CODEN: CLGNA -- Source: Scopus |
