Epithelial-mesenchymal transitions: Twist in development and metastasis Journal Article
| Authors: | Kang, Y.; Massagué, J. |
| Article Title: | Epithelial-mesenchymal transitions: Twist in development and metastasis |
| Abstract: | Epithelial-mesenchymal transitions (EMT) are vital for morphogenesis during embryonic development and are also implicated in the conversion of early stage tumors into invasive malignancies. Several key inducers of EMT are transcription factors that repress E-cadherin expression. A recent report in Cell (Yang et al., 2004) adds Twist to this list and links EMT to the ability of breast cancer cells to enter the circulation and seed metastases. |
| Keywords: | mitogen activated protein kinase; protein expression; unclassified drug; nonhuman; phenotype; animals; gene overexpression; metastasis; breast cancer; gene expression; smad protein; protein; transcription factor; drosophila; embryo development; morphogenesis; immunoglobulin enhancer binding protein; phosphatidylinositol 3 kinase; uvomorulin; morphology; carcinogenesis; scatter factor; tumor suppressor gene; lung metastasis; cell culture; gene identification; nerve cell adhesion molecule; neoplasm metastasis; melanoma cell; short survey; epithelium; cadherins; zinc finger protein; transcription factor snail; transcription factor twist; cytoskeleton; mesoderm; stomach carcinoma; mesenchyme; tissue repair; fibroblast growth factor; gastropoda; humans; human; priority journal; embryonic and fetal development |
| Journal Title: | Cell |
| Volume: | 118 |
| Issue: | 3 |
| ISSN: | 0092-8674 |
| Publisher: | Cell Press |
| Date Published: | 2004-08-06 |
| Start Page: | 277 |
| End Page: | 279 |
| Language: | English |
| DOI: | 10.1016/j.cell.2004.07.011 |
| PUBMED: | 15294153 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Cited By (since 1996):595 -- Export Date: 16 June 2014 -- CODEN: CELLB -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work