Untangling intracellular DNA topology Journal Article
| Authors: | Espeli, O.; Marians, K. J. |
| Article Title: | Untangling intracellular DNA topology |
| Abstract: | The biochemical steps by which bacterial topoisomerases alter the topology of DNA are well known. However, it has been a more vexing task to establish physiological roles and sites of action of the different topoisomerases within the context of the bacterial cell cycle. This difficulty can be attributed in part to the redundancy among the activities of the different enzymes. In this microreview, we will focus on recent progress in understanding the topological structure of the chromosome, analysis of topoisomerase mechanism in single-molecule assays and recent data on the regulation and integration of topoisomerase activity within the cell cycle that have all brought a new perspective to the action of topoisomerases in the bacterial cell. |
| Keywords: | nonhuman; chromosome structure; cell cycle; molecular dynamics; enzyme activity; bacteria (microorganisms); double stranded dna; regulatory mechanism; escherichia coli; cellular distribution; short survey; nucleic acid conformation; bacterial dna; dna, bacterial; enzyme mechanism; dna topoisomerase iv; chromosomes, bacterial; dna topoisomerase; bacteria; bacterial cell; dna topoisomerases; negibacteria; priority journal |
| Journal Title: | Molecular Microbiology |
| Volume: | 52 |
| Issue: | 4 |
| ISSN: | 0950-382X |
| Publisher: | Blackwell Publishing |
| Date Published: | 2004-05-01 |
| Start Page: | 925 |
| End Page: | 931 |
| Language: | English |
| DOI: | 10.1111/j.1365-2958.2004.04047.x |
| PUBMED: | 15130115 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Cited By (since 1996):56 -- Export Date: 16 June 2014 -- CODEN: MOMIE -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work