Endostatin's endpoints - Deciphering the endostatin antiangiogenic pathway Journal Article
| Authors: | Benezra, R.; Rafii, S. |
| Article Title: | Endostatin's endpoints - Deciphering the endostatin antiangiogenic pathway |
| Abstract: | Up until now, the precise mechanism for endostatin's antiangiogenesis action was not known. In a recent report, Abdollahi et al. (2004) have taken advantage of gene array and proteomic analysis to map the antiangiogenic pathways turned on by endostatin. This study resolves some of the controversies surrounding endostatin's biology, and provides a new direction to help dissect the molecular pathways involved in endostatin's selective tumor antiangiogenic effects. |
| Keywords: | signal transduction; vascular endothelial growth factor a; bevacizumab; cell proliferation; protein analysis; cell death; cell survival; gene expression; gene expression profiling; transforming growth factor beta; gelatinase b; angiogenesis; neovascularization, pathologic; phosphorylation; vascular endothelial growth factor receptor-2; proteomics; colorectal carcinoma; endothelium cell; wound healing; endothelial cells; drug mechanism; vasculotropin a; cell migration; short survey; pregnancy; down regulation; dna microarray; microenvironment; tumor growth; thrombospondin 1; angiogenesis inhibitors; antiangiogenic activity; tissue repair; receptors, immunologic; angiogenic factor; stat protein; retinitis; endostatin; integrin alpha5beta1; ephrin a1; protein precursor; kininogen; human; priority journal; endostatins; antigens, cd36; receptors, lipoprotein; receptors, scavenger |
| Journal Title: | Cancer Cell |
| Volume: | 5 |
| Issue: | 3 |
| ISSN: | 1535-6108 |
| Publisher: | Cell Press |
| Date Published: | 2004-03-01 |
| Start Page: | 205 |
| End Page: | 206 |
| Language: | English |
| DOI: | 10.1016/s1535-6108(04)00057-1 |
| PUBMED: | 15050911 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Cited By (since 1996):28 -- Export Date: 16 June 2014 -- CODEN: CCAEC -- Source: Scopus |
