Induction of complete regressions of oncogene-induced breast tumors in mice Conference Paper
| Authors: | Benezra, R.; Henke, E.; Ciarrocchi, A.; Ruzinova, M.; Solit, D.; Rosen, N.; Nolan, D.; Mittal, V.; De Candia, P. |
| Title: | Induction of complete regressions of oncogene-induced breast tumors in mice |
| Conference Title: | 70th Cold Spring Harbor Symposium on Quantitative Biology |
| Abstract: | Over the past decade, mouse models of cancer have come to resemble human disease much more closely than simple subcutaneous or orthotopic systems. Intervention strategies that work on these new model systems are more likely to have an impact clinically. We have shown recently that antiangiogenic stress imposed by loss of Id protein in endothelial progenitor cells results in dramatic central necrosis in breast tumors initiated in mice by overexpression of the her2/neu oncogene. Tumor cells remain viable at the periphery, perhaps via the hypoxic response pathway which allows the lesions to expand. Inhibition of this pathway by the inactivation of the Hif-1α chaperone Hsp90 in combination with antiangiogenic stress leads to the first reported complete regression of these aggressive breast tumors. © 2005 Cold Spring Harbor Laboratory Press. |
| Keywords: | nonhuman; conference paper; animals; mice; mice, knockout; cell viability; gene overexpression; tumor regression; vascularization; necrosis; mice, transgenic; stem cell; endothelium cell; oncogene; breast tumor; cell damage; tumor cell; heat shock protein 90; cell hypoxia; angiogenesis inhibitors; hypoxia inducible factor 1alpha; genes, erbb-2; antiangiogenic activity; benzoquinones; lactams, macrocyclic; hypoxia-inducible factor 1, alpha subunit; mammary neoplasms, experimental; inhibitor of differentiation protein; inhibitor of differentiation proteins |
| Journal Title | Cold Spring Harbor Symposia on Quantitative Biology |
| Volume: | 70 |
| Conference Dates: | 2005 Jun 1-6 |
| Conference Location: | Cold Spring Harbor, NY |
| ISBN: | 0091-7451 |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Date Published: | 2005-01-01 |
| Start Page: | 375 |
| End Page: | 381 |
| Language: | English |
| DOI: | 10.1101/sqb.2005.70.006 |
| PUBMED: | 16869774 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 6" - "Export Date: 24 October 2012" - "CODEN: CSHSA" - "Source: Scopus" |
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