Ten-year outcomes of high-dose, intensity-modulated radiotherapy for localized prostate cancer Journal Article
| Authors: | Alicikus, Z. A.; Yamada, Y.; Zhang, Z.; Pei, X.; Hunt, M.; Kollmeier, M.; Cox, B.; Zelefsky, M. J. |
| Article Title: | Ten-year outcomes of high-dose, intensity-modulated radiotherapy for localized prostate cancer |
| Abstract: | BACKGROUND. The authors investigated long-term tumor control and toxicity outcomes after high-dose, intensity-modulated radiation therapy (IMRT) in patients who had clinically localized prostate cancer. METHODS. Between April 1996 and January 1998, 170 patients received 81 gray (Gy) using a 5-field IMRT technique. Patients were classified according to the National Comprehensive Cancer Network-defined risk groups. Toxicity data were scored according to the Common Terminology Criteria for Adverse Events Version 3.0. Freedom from biochemical relapse, distant metastases, and cause-specific survival outcomes were calculated. The median follow-up was 99 months. RESULTS. The 10-year actuarial prostate-specific antigen relapse-free survival rates were 81% for the low-risk group, 78% for the intermediate-risk group, and 62% for the high-risk group; the 10-year distant metastases-free rates were 100%, 94%, and 90%, respectively; and the 10-year cause-specific mortality rates were 0%, 3%, and 14%, respectively. The 10-year likelihood of developing grade 2 and 3 late genitourinary toxicity was 11% and 5%, respectively; and the 10-year likelihood of developing grade 2 and 3 late gastrointestinal toxicity was 2% and 1%, respectively. No grade 4 toxicities were observed. CONCLUSIONS. To the authors′ knowledge, this report represents the longest followed cohort of patients who received high-dose radiation levels of 81 Gy using IMRT for localized prostate cancer. The findings indicated that high-dose IMRT is well tolerated and is associated with excellent long-term tumor-control outcomes in patients with localized prostate cancer Cancer 2011. © 2010 American Cancer Society. |
| Keywords: | adult; cancer survival; controlled study; treatment outcome; aged; aged, 80 and over; disease-free survival; middle aged; major clinical study; intensity modulated radiation therapy; disease free survival; radiation dose; follow up; follow-up studies; prostate specific antigen; radiation injury; cancer mortality; distant metastasis; risk assessment; prostate cancer; prostate-specific antigen; prostatic neoplasms; intensity-modulated radiotherapy; radiotherapy, intensity-modulated; cancer relapse; radiotherapy planning, computer-assisted; urogenital tract disease; erectile dysfunction; biochemistry; gastrointestinal disease; high-dose |
| Journal Title: | Cancer |
| Volume: | 117 |
| Issue: | 7 |
| ISSN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 2011-04-01 |
| Start Page: | 1429 |
| End Page: | 1437 |
| Language: | English |
| DOI: | 10.1002/cncr.25467 |
| PUBMED: | 21425143 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 23 June 2011" - "CODEN: CANCA" - "Source: Scopus" |
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