Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries report of an NCI workshop, December 3-4, 2003 Journal Article
| Authors: | Stone, H. B.; Moulder, J. E.; Coleman, C. N.; Ang, K. K.; Anscher, M. S.; Barcellos-Hoff, M. H.; Dynan, W. S.; Fike, J. R.; Grdina, D. J.; Greenberger, J. S.; Hauer-Jensen, M.; Hill, R. P.; Kolesnick, R. N.; MacVittie, T. J.; Marks, C.; McBride, W. H.; Metting, N.; Pellmar, T.; Purucker, M.; Robbins, M. E.; Schiestl, R. H.; Seed, T. M.; Tomaszewski, J. E.; Travis, E. L.; Wallner, P. E.; Wolpert, M.; Zaharevitz, D. |
| Article Title: | Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries report of an NCI workshop, December 3-4, 2003 |
| Abstract: | To develop approaches to prophylaxis/protection, mitigation and treatment of radiation injuries, appropriate models are needed that integrate the complex events that occur in the radiation-exposed organism. While the spectrum of agents in clinical use or preclinical development is limited, new research findings promise improvements in survival after whole-body irradiation and reductions in the risk of adverse effects of radiotherapy. Approaches include agents that act on the initial radiochemical events, agents that prevent or reduce progression of radiation damage, and agents that facilitate recovery from radiation injuries. While the mechanisms of action for most of the agents with known efficacy are yet to be fully determined, many seem to be operating at the tissue, organ or whole animal level as well as the cellular level. Thus research on prophylaxis/protection, mitigation and treatment of radiation injuries will require studies in whole animal models. Discovery, development and delivery of effective radiation modulators will also require collaboration among researchers in diverse fields such as radiation biology, inflammation, physiology, toxicology, immunology, tissue injury, drug development and radiation oncology. Additional investment in training more scientists in radiation biology and in the research portfolio addressing radiological and nuclear terrorism would benefit the general population in case of a radiological terrorism event or a large-scale accidental event as well as benefit patients treated with radiation. © 2004 by Radiation Research Society. |
| Keywords: | antibiotic agent; clinical trial; gastrointestinal hemorrhage; nonhuman; conference paper; cancer radiotherapy; animals; unindexed drug; transforming growth factor beta; kidney disease; fas antigen; dexamethasone; radiation injury; protein p53; radiation response; central nervous system; animalia; skin; fibrosis; whole body radiation; kidney; kidney injury; radiation dose fractionation; pentoxifylline; hematopoietic system; lung; radiation injuries; xerostomia; octreotide; antioxidant; radiation hazard; gastrointestinal tract; lung fibrosis; angiotensin 2 receptor antagonist; dipeptidyl carboxypeptidase inhibitor; keratinocyte growth factor; amifostine; fibroblast growth factor; zebrafish; hematologic disease; hemopoietic growth factor; anticoagulant agent; radiation protection; thrombomodulin; androstenediol; central nervous system disease; halofuginone; enema; lung injury; radioprotective agent; misoprostol; sucralfate; manganese superoxide dismutase; proctitis; interleukin 11; salazosulfapyridine; digestive system injury; mercaptamine; primrose oil; humans; human; priority journal; angiotensin; short chain fatty acid |
| Journal Title: | Radiation Research |
| Volume: | 162 |
| Issue: | 6 |
| ISSN: | 0033-7587 |
| Publisher: | Radiation Research Society |
| Date Published: | 2004-12-01 |
| Start Page: | 711 |
| End Page: | 728 |
| Language: | English |
| DOI: | 10.1667/rr3276 |
| PROVIDER: | scopus |
| PUBMED: | 15548121 |
| DOI/URL: | |
| Notes: | Radiat. Res. -- Cited By (since 1996):108 -- Export Date: 16 June 2014 -- CODEN: RAREA -- Source: Scopus |
