Radiotherapeutic implications of the updated ICRP thresholds for tissue reactions related to cataracts and circulatory diseases Conference Paper

  


Authors: Dauer, L. T.; Yorke, E.; Williamson, M.; Gao, Y.; Dauer, Z. L.; Miller, D. L.; Vañó, E.
Title: Radiotherapeutic implications of the updated ICRP thresholds for tissue reactions related to cataracts and circulatory diseases
Conference Title: 4th International Symposium on the System of Radiological Protection (ICRP)
Abstract: Radiation therapy of cancer patients involves a trade-off between a sufficient tumour dose for a high probability of local control and dose to organs at risk that is low enough to lead to a clinically acceptable probability of toxicity. The International Commission on Radiological Protection (ICRP) reviewed epidemiological evidence and provided updated estimates of ‘practical’ threshold doses for tissue injury, as defined at the level of 1% incidence, in ICRP Publication 118. Particular attention was paid to cataracts and circulatory diseases. ICRP recommended nominal absorbed dose threshold for these outcomes as low as 0.5 Gy. Threshold doses for tissue reactions can be reached in some patients during radiation therapy. Modern treatment planning systems do not account for such low doses accurately, and doses to therapy patients from associated imaging procedures are not generally accounted for. While local control is paramount, the observations of ICRP Publication 118 suggest that radiation therapy plans and processes should be examined with particular care. The research needs are discussed in this paper. © 2018, The International Society for Prosthetics and Orthotics.
Keywords: radiation biology; deterministic effects; tissue reactions; cataracts; icrp; threshold doses
Journal Title Annals of the ICRP
Volume: 47
Issue: 3-4
Conference Dates: 2017 Oct 10-12
Conference Location: Paris, France
ISBN: 0146-6453
Publisher: Sage Publications Ltd.  
Date Published: 2018-10-01
Start Page: 196
End Page: 213
Language: English
DOI: 10.1177/0146645318759622
PUBMED: 29741403
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85046800750&doi=10.1177%2f0146645318759622&partnerID=40&md5=15c491a9163c4db532a9e215eae9a57e
Notes: Article -- Export Date: 1 November 2018 -- Source: Scopus
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MSK Authors
  1. Ellen D Yorke
    451 Yorke
  2. Lawrence Dauer
    172 Dauer
  3. Matthew Williamson
    27 Williamson
  4. Yiming Gao
    19 Gao
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