The rise and fall of malignant fibrous histiocytoma Journal Article
| Authors: | Erlandson, R. A.; Antonescu, C. R. |
| Article Title: | The rise and fall of malignant fibrous histiocytoma |
| Abstract: | The term malignant fibrous histiocytoma was coined by Stout and associates in the 1960s to encompass pleomorphic soft tissue sarcomas presumably derived from histiocytes that are capable of fibroblastic transformation. The concept was reaffirmed in the following 2 decades and malignant fibrous histiocytoma thus was regarded as the most common soft tissue tumor in older adults. However, recent more critical clinicopathologic, ultrastructural, and immunohistochemical studies have shown that malignant fibrous histiocytomas are not derived from histiocytic "facultative fibroblasts" and many neoplasms so diagnosed actually are pleomorphic subtypes of other sarcomas. Meticulous electron microscopic and immunohistochemical investigations also found that the more common storiform-pleomorphic, myxoid, and perhaps the giant cell subtypes are composed of variable mixtures of fibroblasts and phenotypically modulated fibroblastic cells, notably myofibroblasts and histiofibroblasts. On the basis of these findings, we propose a new classification for the above subtypes of so-called malignant fibrous histiocytoma, the majority of which are variants of pleomorphic fibrosarcoma. |
| Keywords: | immunohistochemistry; disease classification; conference paper; cancer diagnosis; diagnostic accuracy; phenotype; electron microscopy; classification; cell differentiation; fibrosarcoma; fibroblast; fibroblasts; malignant fibrous histiocytoma; ultrastructure; soft tissue neoplasms; soft tissue tumor; terminology; histiocytoma, benign fibrous; humans; human; priority journal; pleomorphic fibrosarcoma |
| Journal Title: | Ultrastructural Pathology |
| Volume: | 28 |
| Issue: | 5-6 |
| ISSN: | 0191-3123 |
| Publisher: | Informa Healthcare |
| Date Published: | 2004-09-01 |
| Start Page: | 283 |
| End Page: | 289 |
| Language: | English |
| DOI: | 10.1080/019131290882150 |
| PROVIDER: | scopus |
| PUBMED: | 15764577 |
| DOI/URL: | |
| Notes: | Ultrastruct. Pathol. -- Cited By (since 1996):24 -- Export Date: 16 June 2014 -- CODEN: ULPAD -- Source: Scopus |
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