Correlation of clinical and immunological data in a metastatic melanoma patient with heterogeneous tumor responses to ipilimumab therapy Journal Article


Authors: Yuan, J.; Page, D. B.; Ku, G. Y.; Li, Y.; Mu, Z.; Ariyan, C.; Gallardo, H. F.; Roman, R. A.; Heine, A. I.; Terzulli, S. L.; Gnjatic, S.; Ritter, G.; Jungbluth, A. A.; Allison, J. P.; Old, L. J.; Wolchok, J. D.
Article Title: Correlation of clinical and immunological data in a metastatic melanoma patient with heterogeneous tumor responses to ipilimumab therapy
Abstract: Melanoma patients treated with anti-CTLA-4 have shown a range of anti-tumor responses. In this report, we describe the response of a single patient to anti-CTLA-4, with individual lesions disappearing, others stabilizing, and others progressing. These responses can be viewed as a clear manifestation of cancer immunoediting and its three phases of elimination, equilibrium and escape, with each tumor in this patient being at a discrete stage in the process. The patient's course and associated immunological monitoring and other laboratory data are presented in an immunogram, a way to visualize temporal associations between the multiple clinical and laboratory parameters.
Keywords: immunohistochemistry; middle aged; case report; antineoplastic agents; flow cytometry; antineoplastic agent; ipilimumab; melanoma; metastasis; skin neoplasms; drug effect; pathology; monoclonal antibody; skin tumor; immunology; antibodies, monoclonal; cell count; lymphocyte; lymphocytes; cell separation
Journal Title: Cancer Immunity
Volume: 10
ISSN: 1424-9634
Publisher: Academy of Cancer Immunology  
Date Published: 2010-01-01
Start Page: 1
Language: English
PUBMED: 20052966
PROVIDER: scopus
PMCID: PMC2964016
DOI/URL:
Notes: --- - "Cited By (since 1996): 1" - "Export Date: 20 April 2011" - "Source: Scopus"