Targeting cytotoxic T-lymphocyte antigen 4 in immunotherapies for melanoma and other cancers Journal Article
| Authors: | Page, D. B.; Yuan, J.; Wolchok, J. D. |
| Article Title: | Targeting cytotoxic T-lymphocyte antigen 4 in immunotherapies for melanoma and other cancers |
| Abstract: | The immune system can simultaneously protect against tumor growth and sculpt resistant tumor strains. By a variety of mechanisms, anti-cytotoxic T-lymphocyte antigen (CTLA)-4 therapy may shift such opposing forces towards tumor elimination. In recent clinical trials, anti-CTLA-4 therapy induces durable responses that correlate with markers of immune activity, such as antigen-specific CD4+ or CD8+ cytokine release, antitumor antibody formation or cellular phenotype differentiation. However, some patients exhibit atypical responses to anti-CTLA-4 therapy, demonstrating transient/delayed responses or heterogeneity by lesion site. Such atypical responses may offer insight into the mechanism of anti-CTLA-4 therapy. The immunogram - a newly described graphical synthesis of treatment data and immune correlates in individual patients - may help us to confirm, reject or formulate new hypotheses regarding the mechanism of anti-CTLA-4 activity. © 2010 Future Medicine Ltd. |
| Keywords: | treatment response; unclassified drug; overall survival; clinical trial; review; hepatitis; placebo; cancer combination chemotherapy; drug efficacy; drug potentiation; drug safety; nonhuman; paclitaxel; cancer radiotherapy; pancreas cancer; temozolomide; cancer staging; antineoplastic agent; prostate specific antigen; cell function; alpha2b interferon; carboplatin; cytotoxic t lymphocyte antigen 4 antibody; dacarbazine; dendritic cell vaccine; glycoprotein gp 100; interleukin 2; ipilimumab; ticilimumab; cancer immunotherapy; melanoma; drug eruption; leukopenia; lung cancer; steroid; antineoplastic activity; kidney carcinoma; prostate cancer; pruritus; regulatory t lymphocyte; fibrosarcoma; immunotherapy; drug mechanism; ny eso 1 antigen; breast carcinoma; pancreatitis; lymphoma; graft versus host reaction; dna vaccine; melan a; colon perforation; immunomodulating agent; monophenol monooxygenase; peptide vaccine; corticosteroid; colon carcinoma; cytotoxic t lymphocyte antigen 4; granulocyte macrophage colony stimulating factor vaccine; hormone substitution; prostate carcinoma; enterocolitis; uveitis; immune surveillance; hypophysitis; cytotoxic t-lymphocyte antigen 4 blockade; immunoediting; immunogram; tremelimumab; mdx 1379; tumor necrosis factor inhibitor; thyroiditis |
| Journal Title: | Immunotherapy |
| Volume: | 2 |
| Issue: | 3 |
| ISSN: | 1750-743X |
| Publisher: | Future Medicine |
| Date Published: | 2010-05-01 |
| Start Page: | 367 |
| End Page: | 379 |
| Language: | English |
| DOI: | 10.2217/imt.10.21 |
| PROVIDER: | scopus |
| PUBMED: | 20635901 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 3" - "Export Date: 20 April 2011" - "Source: Scopus" |
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