Resection of glioma in an fMRI-defined "split" Broca's area Journal Article


Authors: Kim, J. H.; Amankulor, N. M.; Peck, K. K. ; Brennan, N.; Gutin, P. H.; Holodny, A. I.
Article Title: Resection of glioma in an fMRI-defined "split" Broca's area
Abstract: Gross total resection of gliomas can be limited by the involvement of tumor in eloquent areas. Moreover, lesions can impart cortical reorganization and make the precise determination of hemispheric dominance and localization of language function even more difficult. Preoperative mapping with functional magnetic resonance imaging (fMRI), intraoperative imaging modalities, and intraoperative direct cortical stimulation enable surgeons to map the functional topography of the brain in relation to the tumor and perform a safe maximal resection. In this report, we present a patient with left frontal glioma of complex morphology, wherein the tumor was enveloped by Broca's area on fMRI. Intraoperative mapping and intraoperative magnetic resonance imaging (iMRI) allowed gross total resection of the tumor with preservation of language function and illustrate the utility of multiple contemporary modalities in the surgical management of low-grade gliomas located in eloquent cortices. © 2013 © 2013 Taylor & Francis.
Keywords: functional magnetic resonance imaging; awake craniotomy; broca's area; intraoperative electrocorticography
Journal Title: Neurocase
Volume: 20
Issue: 5
ISSN: 1355-4794
Publisher: Routledge Journals, Taylor & Francis Ltd  
Date Published: 2014-01-01
Start Page: 481
End Page: 486
Language: English
DOI: 10.1080/13554794.2013.826678
PROVIDER: scopus
PUBMED: 23937303
DOI/URL:
Notes: Neurocase -- Export Date: 8 July 2014 -- CODEN: NROCF -- Source: Scopus
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MSK Authors
  1. Nicole Brennan
    21 Brennan
  2. Philip H Gutin
    92 Gutin
  3. Jun Hyun Kim
    3 Kim
  4. Kyung Peck
    34 Peck
  5. Andrei Holodny
    84 Holodny