Preoperative serum albumin is associated with mortality and complications after radical cystectomy Journal Article
| Authors: | Garg, T.; Chen, L. Y.; Kim, P. H.; Zhao, P. T.; Herr, H. W.; Donat, S. M. |
| Article Title: | Preoperative serum albumin is associated with mortality and complications after radical cystectomy |
| Abstract: | Objective: To determine the association between preoperative serum albumin and mortality and postoperative complications after radical cystectomy (RC) and urinary diversion. Patients and Methods: We conducted a retrospective review of 1097 RCs performed for the treatment of bladder cancer between 1992 and 2005. All data were entered prospectively into a hospital-based complications database. We used multivariable logistic regression to assess the association between preoperative serum albumin and complications and mortality ≤90 days of RC, while controlling for preoperative patient and disease characteristics. Results: Low preoperative serum albumin was identified in 14% of the cohort. Preoperative serum albumin was a predictor of postoperative complications (adjusted odds ratio [OR] per unit increase in albumin: 0.61, 95% confidence interval [CI] 0.42-0.90) and 90-day mortality (OR 0.33, 95% CI 0.14-0.75) when controlling for sex, race, age-adjusted Charlson score, body mass index, prior history of abdominal surgery, clinical stage, and neoadjuvant chemotherapy. As serum albumin decreased, the risk of complications and mortality increased. Conclusions: In addition to age-adjusted Charlson score, low preoperative serum albumin is a significant predictor of complications and mortality after RC. Serum albumin testing can be used to identify individuals at high-risk of morbidity and mortality. © 2013 The Authors. BJU International © 2013 BJU International. |
| Keywords: | cancer survival; controlled study; aged; cancer surgery; major clinical study; area under the curve; cancer staging; outcome assessment; follow up; preoperative evaluation; disease association; cohort analysis; medical record review; retrospective study; bladder cancer; urinary bladder neoplasms; cancer mortality; high risk patient; patient identification; postoperative complication; postoperative complications; survival time; albumin; cystectomy; urinary diversion; sex difference; age distribution; predictive value; receiver operating characteristic; human; male; female; priority journal; article; hypoalbuminaemia |
| Journal Title: | BJU International |
| Volume: | 113 |
| Issue: | 6 |
| ISSN: | 1464-4096 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2014-06-01 |
| Start Page: | 918 |
| End Page: | 923 |
| Language: | English |
| DOI: | 10.1111/bju.12405 |
| PROVIDER: | scopus |
| PUBMED: | 24053616 |
| PMCID: | PMC4203702 |
| DOI/URL: | |
| Notes: | BJU Int. -- Export Date: 8 July 2014 -- CODEN: BJINF -- Source: Scopus |
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