Prospective analysis of penile length changes after radical prostatectomy Journal Article


Authors: Berookhim, B. M.; Nelson, C. J.; Kunzel, B.; Mulhall, J. P.; Narus, J. B.
Article Title: Prospective analysis of penile length changes after radical prostatectomy
Abstract: Objectives: • To assess the impact of radical prostatectomy (RP) on penile dimensions. • To assess the impact of phosphodiesterase-5 inhibitor (PDE5i) use on penile length changes. Patients and Methods: • Men undergoing RP were enrolled in this prospective study before surgery. Demographic, clinical and PDE5i frequency-of-use data were collected. • Erectile function was measured using the erectile function domain (EFD) of the International Index of Erectile Function. • A single evaluator measured stretched flaccid penile length (SFPL) before RP, and at 2 and 6 months after RP. • Repeated measures analysis was used to test differences in SFPL between timepoints. Pearson correlation was used for univariate analyses and multiple regression was used for multivariable analysis. Results: • A total of 118 patients were evaluated at baseline, with 76 and 63 patients evaluated at 2 and 6 months, respectively. • At 2 months, there was a 2.4-mm mean decrease in SFPL, while at 6 months there was no significant difference. • At 6 months, those subjects who took a daily PDE5i had no SFPL loss (n = 36, 1±6.7 mm gain, P = 0.37 compared with baseline), while those subjects who did not consistently take a PDE5i had SFPL loss (n = 27, 4.4±6.6 mm loss, P < 0.002 compared with baseline). • In multivariable analysis, PDE5i use at 6 months and 6-month EFD score without on-demand PDE5i were significant predictors of 6-month SFPL loss, suggesting that an increase in these variables leads to SFPL preservation. Conclusions: • In this rigorously conducted prospective study of SFPL changes after RP, there was evidence of SFPL loss at 2 months, but not at 6 months after RP. • PDE5i use moderated SFPL loss, with patients who regularly used PDE5i having no loss in SFPL. © 2013 The Authors.
Keywords: middle aged; prospective study; prospective studies; drug effect; histology; prostate cancer; prostatectomy; radical prostatectomy; erectile dysfunction; organ size; penile rehabilitation; phosphodiesterase v inhibitor; penis; phosphodiesterase 5 inhibitors; penile length; humans; human; male; article
Journal Title: BJU International
Volume: 113
Issue: 5 B
ISSN: 1464-4096
Publisher: Wiley Blackwell  
Date Published: 2014-05-01
Start Page: E131
End Page: E136
Language: English
DOI: 10.1111/bju.12443
PROVIDER: scopus
PUBMED: 24053766
DOI/URL:
Notes: BJU Int. -- Export Date: 8 July 2014 -- CODEN: BJINF -- Source: Scopus
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MSK Authors
  1. John P Mulhall
    459 Mulhall
  2. Joseph B Narus
    20 Narus
  3. Christian Nelson
    294 Nelson
  4. Brian Kunzel
    5 Kunzel