Chemotherapy-Induced Lung Disease Journal Article


Authors: Vander Els, N. J.; Stover, D. E.
Article Title: Chemotherapy-Induced Lung Disease
Abstract: Chemotherapy-induced lung disease (CILD) can be caused by multiple agents. The diagnosis should be considered in any patient who develops pulmonary symptoms during or after treatment with chemotherapy. It is a diagnosis made by exclusion of other etiologies, especially recurrent tumor or infection. The most common clinical presentations are interstitial pneumonitis/fibrosis, hypersensitivity pneumonitis, and capillary leak syndrome. The clinical characteristics of bleomycin, mitomycin, carmustine, and methotrexate have been well characterized, while newer syndromes caused by gemcitabine, paclitaxel, docetaxel, and fludarabine are being recognized. The clinical approach to patients with suspected CILD must be tailored to the individual patient according to their underlying disease and treatment history, with special attention to the nature of their immunocompromise. Diagnostic procedures are performed to the extent needed to exclude other likely diagnoses. For patients with limited pulmonary reserve, empiric therapy may be a reasonable option.
Keywords: cancer chemotherapy; antibiotic agent; busulfan; fludarabine; review; gemcitabine; paclitaxel; chemotherapy; methotrexate; lymph node dissection; lung toxicity; etoposide; lung disease; oxygen therapy; alkylating agent; cyclophosphamide; melphalan; recurrent infection; antineoplastic activity; carmustine; ifosfamide; lomustine; procarbazine; vinblastine; docetaxel; lung metastasis; immune response; drug mechanism; bleomycin; vindesine; pleura effusion; azathioprine; taxane derivative; mitomycin; retinoic acid; chlorambucil; drug induced disease; antimetabolite; bronchospasm; mercaptopurine; interstitial pneumonia; lung hemorrhage; nitrosourea derivative; bronchiolitis; lung injury; hypersensitivity; capillary leak syndrome; vein occlusion; pulmonary toxicity; capillary permeability; semustine; nucleoside derivative; cancer; human
Journal Title: Clinical Pulmonary Medicine
Volume: 11
Issue: 2
ISSN: 1068-0640
Publisher: Lippincott Williams & Wilkins  
Date Published: 2004-03-01
Start Page: 84
End Page: 91
Language: English
DOI: 10.1097/01.cpm.0000117766.07651.f8
PROVIDER: scopus
DOI/URL:
Notes: Clin. Pulm. Med. -- Cited By (since 1996):2 -- Export Date: 16 June 2014 -- CODEN: CPMEF -- Source: Scopus
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