Multimodal treatment strategies combining neoadjuvant hormonal therapy and/or chemotherapy with radical prostatectomy in high-risk localised prostate cancer Journal Article


Author: Eastham, J. A.
Article Title: Multimodal treatment strategies combining neoadjuvant hormonal therapy and/or chemotherapy with radical prostatectomy in high-risk localised prostate cancer
Abstract: By combining the readily available clinical parameters of tumour stage, Gleason score of the diagnostic biopsy specimen and serum prostate-specific antigen level, men with newly diagnosed prostate cancer can be assessed as to their risk of treatment failure after radiotherapy or radical prostatectomy. For men considered to be at high-risk of treatment failure after local therapy alone, multimodal treatment strategies may result in improved cancer-control outcomes. This strategy has proven effective in the setting of clinical stage T3-T4 tumours in which the combination of radiotherapy followed by hormonal therapy has improved patient survival. The benefit of neoadjuvant or adjuvant hormonal and/or chemotherapy followed by radical prostatectomy in this setting is unclear but is the subject of ongoing or planned Phase III clinical trials. These studies will help examine the role of multimodal treatment strategies in these high-risk patients.
Keywords: cancer survival; treatment outcome; disease-free survival; treatment failure; clinical trial; neutropenia; review; doxorubicin; cancer risk; drug potentiation; paclitaxel; neoadjuvant therapy; chemotherapy; cancer staging; antineoplastic agent; prostate specific antigen; carboplatin; quality of life; erythropoietin; etoposide; antineoplastic combined chemotherapy protocols; deep vein thrombosis; tumor biopsy; antineoplastic activity; vinblastine; high risk patient; risk assessment; docetaxel; prostate cancer; lung embolism; prostate-specific antigen; prostatic neoplasms; randomized controlled trials; probability; prostatectomy; thromboembolism; mitoxantrone; scoring system; warfarin; radical prostatectomy; hydrocortisone; ketoconazole; antineoplastic agents, hormonal; life expectancy; granulocytopenia; estramustine; clinical trials, phase iii; humans; human; male
Journal Title: Expert Opinion on Investigational Drugs
Volume: 13
Issue: 1
ISSN: 1354-3784
Publisher: Taylor & Francis Group  
Date Published: 2004-01-01
Start Page: 39
End Page: 46
Language: English
DOI: 10.1517/13543784.13.1.39
PROVIDER: scopus
PUBMED: 14680451
DOI/URL:
Notes: Expert Opin. Invest. Drugs -- Cited By (since 1996):6 -- Export Date: 16 June 2014 -- CODEN: EOIDE -- Source: Scopus
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  1. James Eastham
    422 Eastham