Neoadjuvant treatment of high-risk, clinically localized prostate cancer prior to radical prostatectomy Journal Article
| Authors: | Pietzak, E. J.; Eastham, J. A. |
| Article Title: | Neoadjuvant treatment of high-risk, clinically localized prostate cancer prior to radical prostatectomy |
| Abstract: | Multimodal strategies combining local and systemic therapy offer the greatest chance of cure for many with men with high-risk prostate cancer who may harbor occult metastatic disease. However, no systemic therapy combined with radical prostatectomy has proven beneficial. This was in part due to a lack of effective systemic agents; however, there have been several advancements in the metastatic and castrate-resistant prostate cancer that might prove beneficial if given earlier in the natural history of the disease. For example, novel hormonal agents have recently been approved for castration-resistant prostate cancer with some early phase II neoadjuvant showing promise. Additionally, combination therapy with docetaxel-based chemohormonal has demonstrated a profound survival benefit in metastatic hormone-naïve patients and might have a role in eliminating pre-existing ADT-resistant tumor cells in the neoadjuvant setting. The Cancer and Leukemia Group B (CALGB)/Alliance 90203 trial has finished accrual and should answer the question as to whether neoadjuvant docetaxel-based chemohormonal therapy provides an advantage over prostatectomy alone. There are also several promising targeted agents and immunotherapies under investigation in phase I/II trials with the potential to provide benefit in the neoadjuvant setting. © 2016, Springer Science+Business Media New York. |
| Keywords: | neoadjuvant therapy; prostate cancer; radical prostatectomy; chemohormonal therapy |
| Journal Title: | Current Urology Reports |
| Volume: | 17 |
| Issue: | 5 |
| ISSN: | 1527-2737 |
| Publisher: | Springer |
| Date Published: | 2016-05-01 |
| Start Page: | 37 |
| Language: | English |
| DOI: | 10.1007/s11934-016-0592-4 |
| PROVIDER: | scopus |
| PUBMED: | 26968417 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 4 April 2016 -- Source: Scopus |
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