Aberrant mRNA translation in cancer pathogenesis: An old concept revisited comes finally of age Journal Article
| Author: | Pandolfi, P. P. |
| Article Title: | Aberrant mRNA translation in cancer pathogenesis: An old concept revisited comes finally of age |
| Abstract: | As the molecular processes that control mRNA translation and ribosome biogenesis in the eukaryotic cell are extremely complex and multilayered, their deregulation can in principle occur at multiple levels, leading to both disease and cancer pathogenesis. For a long time, it was speculated that disruption of these processes may participate in tumorigenesis, but this notion was, until recently, solely supported by correlative studies. Strong genetic support is now being accrued, while new molecular links between tumor-suppressive and oncogenic pathways and the control of protein synthetic machinery are being unraveled. The importance of aberrant protein synthesis in tumorigenesis is further underscored by the discovery that compounds such as Rapamycin, known to modulate signaling pathways regulatory of this process, are effective anticancer drugs. A number of fundamental questions remain to be addressed and a number of novel ones emerge as this exciting field evolves. |
| Keywords: | gene mutation; genetics; review; nonhuman; antineoplastic agent; neoplasm; neoplasms; animal; metabolism; animals; cancer susceptibility; carcinogenesis; oncogene; tumor suppressor gene; correlation analysis; messenger rna; protein synthesis; eukaryota; protein biosynthesis; cell size; tumor suppressor; rapamycin; biogenesis; ribosomes; nucleolus; ribosome; cancer; humans; human; priority journal; mrna translation; dkc1 |
| Journal Title: | Oncogene |
| Volume: | 23 |
| Issue: | 18 |
| ISSN: | 0950-9232 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2004-04-19 |
| Start Page: | 3134 |
| End Page: | 3137 |
| Language: | English |
| DOI: | 10.1038/sj.onc.1207618 |
| PROVIDER: | scopus |
| PUBMED: | 15094762 |
| DOI/URL: | |
| Notes: | Oncogene -- Cited By (since 1996):39 -- Export Date: 16 June 2014 -- CODEN: ONCNE -- Source: Scopus |
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