Cooperative translational control of gene expression by Ras and Akt in cancer Journal Article
| Authors: | Parsa, A. T.; Holland, E. C. |
| Article Title: | Cooperative translational control of gene expression by Ras and Akt in cancer |
| Abstract: | Ras and Akt are signaling proteins that mediate fundamental aspects of normal growth and development in many organisms. When the Ras and Akt pathways become overly active, malignant transformation of normal tissue can occur. The combined activity of these two proteins has generated the transformation of human cell cultures and tumor formation in mice. In this review we highlight malignant glioma as a tumor type in which Ras and Akt pathways cooperate to cause tumorigenesis and regulate translation. The downstream components of these pathways have provided therapeutic targets that are currently being tested in clinical trials. |
| Keywords: | signal transduction; mitogen activated protein kinase; protein kinase b; s6 kinase; unclassified drug; proto-oncogene proteins; disease course; review; nonhuman; antineoplastic agents; pathophysiology; glioma; translation initiation; animals; mice; gene expression; genetic transcription; enzyme activation; phosphatidylinositol 3 kinase; central nervous system neoplasms; carcinogenesis; cell transformation, neoplastic; postoperative complication; molecular mechanics; tumor suppressor gene; gene expression regulation, neoplastic; enzyme phosphorylation; 5' untranslated region; protein-serine-threonine kinases; glioblastoma; proto-oncogene proteins c-akt; initiation factor 4e; binding protein; gene control; ras protein; 3' untranslated region; molecular interaction; molecular biology; codon; sequence homology; proto-oncogene proteins p21(ras); oncogene ras; protein derivative; fatality; target of rapamycin kinase; peptide chain initiation, translational; humans; human; elf2alpha protein |
| Journal Title: | Trends in Molecular Medicine |
| Volume: | 10 |
| Issue: | 12 |
| ISSN: | 1471-4914 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2004-12-01 |
| Start Page: | 607 |
| End Page: | 613 |
| Language: | English |
| DOI: | 10.1016/j.molmed.2004.10.009 |
| PROVIDER: | scopus |
| PUBMED: | 15567331 |
| DOI/URL: | |
| Notes: | Trends Mol. Med. -- Cited By (since 1996):38 -- Export Date: 16 June 2014 -- CODEN: TMMRC -- Source: Scopus |
