Expression of p21(ras) in normal and malignant human tissues: Lack of association with proliferation and malignancy Journal Article

   

Authors:	Chesa, P. G.; Rettig, W. J.; Melamed, M. R.; Old, L. J.; Niman, H. L.
Article Title:	Expression of p21(ras) in normal and malignant human tissues: Lack of association with proliferation and malignancy
Abstract:	Proteins encoded by cellular ras oncogenes (p21(ras)) are expressed in a wide variety of malignant tumors, including carcinomas, lymphomas, and neuroectodermal tumors. The function of p21(ras) in these tumors and the distribution and role of p21(ras) in corresponding normal tissues are unclear. This immunohistochemical study examined the relationship between p21(ras) expression and malignant transformation, cellular differentiation, and proliferative activity in vivo. p21(ras) was found to be widely expressed in normal tissues, but within those tissues expression was often sharply restricted to cells at specific stages of differentiation; terminally differentiated cells generally showed stronger reactivity with antibodies to p21(ras) than did rapidly proliferating cells. Fetal and adult tissues and corresponding patterns of p21(ras) expression, and the distribution of p21(ras) in neoplasms paralleled the pattern in normal tissue from which they were derived. Thus, p21(ras) seems to play a role in many fully differentiated cell types, and levels of p21(ras) expression do not correlate with proliferative activity in normal cells or, in contrast to past reports, with the transformed phenotype.
Keywords:	adult; oncoprotein; human cell; genetics; proto-oncogene proteins; comparative study; neoplasm; neoplasms; pancreas; cell division; breast; central nervous system; cell transformation, neoplastic; oncogenes; monoclonal antibody; enzyme immunoassay; immunoenzyme techniques; oncogene; liver; antibodies, monoclonal; kidney; tissue distribution; cell transformation; lymphoma; carcinoma; fetus; small intestine; protein p21; neuroectoderm tumor; esophagus; mouth; oncogene ras; peripheral nervous system; muscle; bladder; female genital system; endocrine system; cartilage; respiratory system; large intestine; male genital system; cancer; human; male; female; priority journal; article; support, u.s. gov't, p.h.s.; support, u.s. gov't, non-p.h.s.; proto-oncogene protein p21(ras); proto oncogene proteins; proto oncogene protein p21(ras)
Journal Title:	Proceedings of the National Academy of Sciences of the United States of America
Volume:	84
Issue:	10
ISSN:	0027-8424
Publisher:	National Academy of Sciences
Date Published:	1987-05-01
Start Page:	3234
End Page:	3238
Language:	English
DOI:	10.1073/pnas.84.10.3234
PUBMED:	3554234
PROVIDER:	scopus
PMCID:	PMC304843
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023333003&doi=10.1073%2fpnas.84.10.3234&partnerID=40&md5=54eecec43af50ad5dc90f21705d2623b
Notes:	Article -- Export Date: 5 February 2021 -- Source: Scopus

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