Brain metastases Journal Article
| Authors: | Omuro, A. M. P.; Abrey, L. E. |
| Article Title: | Brain metastases |
| Abstract: | Despite advances in the treatment of cancer, brain metastases appear to be increasing in frequency and are associated with a poor prognosis. Type of tumor, age, performance status, and extent of systemic disease are important prognostic factors that should be taken into consideration when making treatment decisions. Patients with a good performance status and controlled systemic disease may benefit from aggressive focal therapies (surgery or radiosurgery). Whole brain radiotherapy seems to increase local control but is associated with the risk of delayed cognitive deterioration in long-term survivors. In spite of this, whole brain radiotherapy remains the standard of care for those patients with poorer prognosis and for the treatment of recurrence after focal therapy. Chemotherapy has a limited role in the treatment of brain metastases but should be considered in selected patient populations. Copyright © 2004 by Current Science Inc. |
| Keywords: | cancer survival; cancer surgery; unclassified drug; clinical trial; review; cancer recurrence; gastrointestinal hemorrhage; pathophysiology; cancer radiotherapy; neurotoxicity; brain tumor; brain neoplasms; antineoplastic agent; medical decision making; disease association; metastasis; dexamethasone; steroid; pathology; age; hyperglycemia; disease severity; etiracetam; radiosurgery; dementia; brain metastasis; cognitive defect; seizure; drug metabolism; intestine perforation; misonidazole; behavior disorder; cancer control; anticonvulsive agent; radiosensitizing agent; ataxia; tumor classification; valproic acid; opportunistic infection; anticoagulant agent; broxuridine; myopathy; incontinence; intracranial hypertension; humans; prognosis; human; efaproxil; motezafin |
| Journal Title: | Current Neurology and Neuroscience Reports |
| Volume: | 4 |
| Issue: | 3 |
| ISSN: | 1528-4042 |
| Publisher: | Springer |
| Date Published: | 2004-05-01 |
| Start Page: | 205 |
| End Page: | 210 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 15102346 |
| DOI: | 10.1007/s11910-004-0040-6 |
| DOI/URL: | |
| Notes: | Curr. Neurol. Neurosci. Rep. -- Cited By (since 1996):11 -- Export Date: 16 June 2014 -- Source: Scopus |
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