Non-kinase second-messenger signaling: New pathways with new promise Journal Article
| Authors: | Springett, G. M.; Kawasaki, H.; Spriggs, D. R. |
| Article Title: | Non-kinase second-messenger signaling: New pathways with new promise |
| Abstract: | Intercellular signaling by growth factors, hormones and neurotransmitters produces second messenger molecules such as cyclic adenosine monophosphate (cAMP) and diacylglycerol (DAG). Protein Kinase A and Protein Kinase C are the principal effector proteins of these prototypical second messengers in certain cell types. Recently, novel receptors for CAMP and DAG have been identified. These proteins, designated EPAC (Exchange Protein directly Activated by cAMP) or cAMP-GEF (cAMP regulated Guanine nucleotide Exchange Factor) and CalDAG-GEF (Calcium and Diacylglycerol regulated Guanine nucleotide Exchange-Factor) or RbsGRP (Ras Guanine nucleotide Releasing Protein) are able to mediate some of the physiologic effects of the second messengers in a protein-kinase-independent fashion. These proteins are exchange factors for Ras family GTPases that operate in pathways that run parallel to the classic kinase-dependent pathways. The rapidly emerging recognition of the functions of these "non- kinase" effectors in diverse processes such as insulin secretion, thymocyte development, asthma and malignant transformation creates new opportunities for discovery and identifies potential new therapeutic targets. © 2004 Wiley Periodicals, Inc. |
| Keywords: | signal transduction; unclassified drug; dna binding protein; dna-binding proteins; review; nonhuman; animal; metabolism; animals; cell maturation; cell protein; physiology; cell type; chemistry; enzyme regulation; cyclic amp; insulin; effector cell; protein kinase c; ras protein; asthma; hormone; cell transport; malignant transformation; growth factor; thymocyte; diacylglycerol; secretion; guanine nucleotide exchange factors; cyclic amp dependent protein kinase; second messenger; guanine nucleotide exchange factor; guanosine triphosphatase; mast cell; mast cells; neurotransmitter release; neurotransmitter; second messenger systems; process monitoring; humans; human; calcium diacylglycerol regulated guanine nucleotide exchange factor; cyclic amp regulated guanine nucleotide exchange factor; protein epac; rasgrp1 protein, human; insulin release |
| Journal Title: | BioEssays |
| Volume: | 26 |
| Issue: | 7 |
| ISSN: | 0265-9247 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2004-07-01 |
| Start Page: | 730 |
| End Page: | 738 |
| Language: | English |
| DOI: | 10.1002/bies.20057 |
| PROVIDER: | scopus |
| PUBMED: | 15221855 |
| DOI/URL: | |
| Notes: | BioEssays -- Cited By (since 1996):53 -- Export Date: 16 June 2014 -- CODEN: BIOEE -- Source: Scopus |
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