Suppressing nucleotide exchange to inhibit KRAS-mutant tumors Editorial

  


Authors: Zhao, Y.; Xue, J. Y.; Lito, P.
Title: Suppressing nucleotide exchange to inhibit KRAS-mutant tumors
Abstract: Guanine nucleotide exchange factors (GEF) control the rate-limiting step of physiologic RAS activa-tion. In this issue of Cancer Discovery, Hofmann and colleagues describe the discovery of a selective inhibitor targeting the GEF, SOS1, along with its preclinical effects in suppressing KRAS-mutant tumor growth. © 2021 American Association for Cancer Research.
Journal Title: Cancer Discovery
Volume: 11
Issue: 1
ISSN: 2159-8274
Publisher: American Association for Cancer Research  
Date Published: 2021-01-01
Start Page: 17
End Page: 19
Language: English
DOI: 10.1158/2159-8290.Cd-20-1331
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100232325&doi=10.1158%2f2159-8290.CD-20-1331&partnerID=40&md5=e002218e81e6c5dcc2392554abf8ea88
Notes: Note -- Export Date: 1 March 2021 -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Piro Lito
    58 Lito
  2. Yulei Zhao
    8 Zhao
Related MSK Work