Gender and lung cancer Journal Article
| Authors: | Rivera, M. P.; Stover, D. E. |
| Article Title: | Gender and lung cancer |
| Abstract: | Accumulating data suggest that the risks for development of lung cancer are different in women compared with men. An increased susceptibility in women to the adverse effects of tobacco may be due to higher levels of DNA adducts, decreased DNA repair capacity, increased frequency of mutations in tumor suppressor genes, and hormonal differences. There are many sex and gender differences in lung cancer presentation, including a greater proportion of adenocarcinoma among women, a greater representation of women in cohorts of younger patients who have lung cancer, and women who do not smoke are more likely to be diagnosed with lung cancer than men. When guidelines for screening, preventive therapies, and treatment options for lung cancer are outlined these differences should be considered. |
| Keywords: | cancer survival; review; cigarette smoking; cancer risk; lung neoplasms; incidence; risk factors; lung cancer; risk factor; cancer mortality; nicotine; sex difference; lung carcinogenesis; sex factors; estradiol; antiestrogen; hormone substitution; hormones; carcinogen; polycyclic aromatic hydrocarbon; humans; human; male; female; priority journal; nitrosamine |
| Journal Title: | Clinics in Chest Medicine |
| Volume: | 25 |
| Issue: | 2 |
| ISSN: | 0272-5231 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2004-06-01 |
| Start Page: | 391 |
| End Page: | 400 |
| Language: | English |
| DOI: | 10.1016/j.ccm.2004.01.006 |
| PROVIDER: | scopus |
| PUBMED: | 15099898 |
| DOI/URL: | |
| Notes: | Clin. Chest Med. -- Cited By (since 1996):31 -- Export Date: 16 June 2014 -- CODEN: CCHMD -- Source: Scopus |
