Missed micrometastatic disease in breast cancer Journal Article
| Authors: | Quan, M. L.; Cody, H. S. 3rd |
| Article Title: | Missed micrometastatic disease in breast cancer |
| Abstract: | In the era of sentinel lymph node (SLN) biopsy for breast cancer, ultrastaging by enhanced pathologic techniques (serial sections and/or immunohistochemical [IHC] staining) has become logistically feasible for the first time. Retrospective studies suggest that SLN (and bone marrow) micrometastases detected by these methods are prognostically significant, but controversy still surrounds the significance of micrometastases detected only by IHC, and especially of isolated tumor cells. This heterogeneity among micrometastases may confound the interpretation of current prospective clinical trials that aim to determine their significance. A major challenge for future investigations will be to determine if SLN and bone marrow micrometastases represent similar or distinct biologic phenomena, and whether this distinction will have any implications for treatment. © 2004 Elsevier Inc. All rights reserved. |
| Keywords: | immunohistochemistry; cancer survival; clinical feature; pathogenesis; review; cancer diagnosis; lymph node dissection; lymphatic metastasis; neoplasm staging; sentinel lymph node biopsy; diagnostic procedure; metastasis; breast cancer; bone marrow; breast neoplasms; axillary lymph node; feasibility study; statistical significance; reverse transcriptase polymerase chain reaction; neoplasm metastasis; outcomes research; technique; bone marrow metastasis; neoplasm circulating cells; humans; prognosis; human; priority journal |
| Journal Title: | Seminars in Oncology |
| Volume: | 31 |
| Issue: | 3 |
| ISSN: | 0093-7754 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2004-06-01 |
| Start Page: | 311 |
| End Page: | 317 |
| Language: | English |
| DOI: | 10.1053/j.seminoncol.2004.03.012 |
| PROVIDER: | scopus |
| PUBMED: | 15190487 |
| DOI/URL: | |
| Notes: | Semin. Oncol. -- Cited By (since 1996):9 -- Export Date: 16 June 2014 -- CODEN: SOLGA -- Source: Scopus |
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