Lymphovascular invasion enhances the prediction of non-sentinel node metastases in breast cancer patients with positive sentinel nodes Journal Article


Authors: Weiser, M. R.; Montgomery, L. L.; Tan, L. K.; Susnik, B.; Leung, D. H. Y.; Borgen, P. I.; Cody, H. S. 3rd
Article Title: Lymphovascular invasion enhances the prediction of non-sentinel node metastases in breast cancer patients with positive sentinel nodes
Abstract: Background: Fifty percent of patients with sentinel lymph node (SLN) metastases have no metastatic disease in non-SLNs on axillary lymph node dissection (ALND). The goal of this study is to determine which patients have metastatic disease limited to the SLN, and, therefore, may not require completion ALND. Methods: Of the first 1000 patients undergoing SLN biopsy at Memorial Sloan-Kettering Cancer Center, using a combined blue dye and isotope technique, 231 (26%) had positive SLN. Of these, 206 underwent completion ALND. They are the study group for this report. Results: The likelihood of non-SLN metastasis was inversely related to three clinicopathologic variables: tumor size ≤ 1.0 cm; absence of lymphovascular invasion (LVI); and SLN micrometastases (≤ 2 mm). None of 24 patients with all three predictive factors had non-SLN metastases, whereas 58% of patients with none of the factors had disease in the non-SLN. Conclusion: Patients with small breast cancers, no LVI, and SLN micrometastases have a low risk of non-SLN metastases, and may not require completion ALND.
Keywords: adult; controlled study; human tissue; aged; aged, 80 and over; middle aged; major clinical study; cancer patient; lymph node metastasis; sentinel node; lymph node dissection; lymph nodes; lymphatic metastasis; neoplasm staging; sensitivity and specificity; sentinel lymph node; lymph node excision; sentinel lymph node biopsy; breast cancer; tumor volume; breast neoplasms; prediction; lymph vessel; axillary lymph node; neoplasm invasiveness; axilla; analysis of variance; frozen sections; carcinoma, ductal, breast; humans; prognosis; human; female; article; radioisotope diagnosis
Journal Title: Annals of Surgical Oncology
Volume: 8
Issue: 2
ISSN: 1068-9265
Publisher: Springer  
Date Published: 2001-03-01
Start Page: 145
End Page: 149
Language: English
DOI: 10.1007/s10434-001-0145-y
PUBMED: 11258779
PROVIDER: scopus
DOI/URL:
Notes: Presented at the 53rd Annual Meeting of the Society of Surgical Oncology; 2000 Mar 16-19; New Orleans, LA -- Export Date: 21 May 2015 -- Source: Scopus
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Citation Impact
MSK Authors
  1. Lee K Tan
    144 Tan
  2. Hiram S Cody III
    235 Cody
  3. Denis Heng Yan Leung
    114 Leung
  4. Barbara Susnik
    8 Susnik
  5. Patrick I Borgen
    253 Borgen
  6. Martin R Weiser
    437 Weiser