Ocular presentation of primary central nervous system lymphoma: Diagnosis and treatment Journal Article

  

Authors:	Hormigo, A.; Abrey, L.; Heinemann, M. H.; Deangelis, L. M.
Article Title:	Ocular presentation of primary central nervous system lymphoma: Diagnosis and treatment
Abstract:	Primary ocular lymphoma (POL), a lymphoma of the globe, is a restricted form of primary central nervous system lymphoma (PCNSL) that often progresses to the brain and meninges; frequently it is misdiagnosed until central nervous system (CNS) lymphoma develops. The optimal treatment has not yet been identified. We retrospectively reviewed the course and the treatment of POL in 31 patients. Seventeen patients were treated for isolated POL (group A) and 14 were treated only after CNS disease was diagnosed (group B). The treatment in both groups consisted of systemic chemotherapy, chemotherapy plus radiotherapy (RT) or RT alone. In group A, nine patients (53%) developed CNS progression and five (29%) had ocular recurrence. In group B, seven (50%) had CNS progression and three (21%) ocular relapse. To control for diagnostic lead time, median survival was calculated from initial ocular symptoms and was 60 months in group A and 35 months in group B (P < 0.05). Ocular lymphoma responds to a variety of therapies but treatment with chemotherapy and/or ocular radiotherapy (ORT) failed to prevent CNS progression. Patients whose ocular disease was identified and treated before CNS progression had a significantly improved survival.
Keywords:	adult; cancer chemotherapy; cancer survival; clinical article; controlled study; aged; aged, 80 and over; middle aged; survival rate; treatment failure; retrospective studies; prednisone; clinical feature; disease course; review; cancer recurrence; doxorubicin; cancer patient; cancer radiotherapy; primary central nervous system lymphoma; cytarabine; methotrexate; neoplasm recurrence, local; cyclophosphamide; vincristine; retrospective study; procarbazine; central nervous system neoplasms; survival time; symptom; non-hodgkin's lymphoma; lymphoma, non-hodgkin; disease progression; drug response; recurrent disease; uveitis; central nervous system disease; patient; vitreous body; eye tumor; eye neoplasms; humans; human; male; female; priority journal; primary ocular lymphoma; vitreitis
Journal Title:	British Journal of Haematology
Volume:	126
Issue:	2
ISSN:	0007-1048
Publisher:	John Wiley & Sons
Date Published:	2004-07-01
Start Page:	202
End Page:	208
Language:	English
DOI:	10.1111/j.1365-2141.2004.05028.x
PROVIDER:	scopus
PUBMED:	15238140
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-3242714878&partnerID=40&md5=d3ffa60a04b0a167357149eb399dee01
Notes:	Br. J. Haematol. -- Cited By (since 1996):53 -- Export Date: 16 June 2014 -- CODEN: BJHEA -- Source: Scopus

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