Primary CNS lymphoma with intraocular involvement: International PCNSL Collaborative Group Report Journal Article
| Authors: | Grimm, S. A.; McCannel, C. A.; Omuro, A. M. P.; Ferreri, A. J. M.; Blay, J. Y.; Neuwelt, E. A.; Siegal, T.; Batchelor, T.; Jahnke, K.; Shenkier, T. N.; Hall, A. J.; Graus, F.; Herrlinger, U.; Schiff, D.; Raizer, J.; Rubenstein, J.; Laperriere, N.; Thiel, E.; Doolittle, N.; Iwamoto, F. M.; Abrey, L. E. |
| Article Title: | Primary CNS lymphoma with intraocular involvement: International PCNSL Collaborative Group Report |
| Abstract: | Objective: To describe the demographics, diagnostic details, therapeutic management, and outcome in patients with primary CNS lymphoma (PCNSL) with ocular involvement. Methods: A retrospective study of 221 patients was assembled from 16 centers in seven countries. Only HIV-negative, immunocompetent patients with brain and ocular lymphoma were included; none had systemic lymphoma. Results: Median age at diagnosis was 60. Fifty-seven percent were women. Median Eastern Cooperative Oncology Group performance status was 2. Ocular disturbance and behavioral/cognitive changes were the most common presenting symptoms. Diagnosis of lymphoma was made by brain biopsy (147), vitrectomy (65), or CSF cytology (11). Diagnosis of intraocular lymphoma was made by vitrectomy/choroidal/retinal biopsy (90) or clinical ophthalmic examination (141). CSF cytology was positive in 23%. Treatment information was available for 176 patients. A total of 102 received dedicated ocular therapy (ocular radiotherapy 79, intravitreal methotrexate 22, and both 1) in addition to treatment for their brain lymphoma. Sixty-nine percent progressed at a median of 13 months; sites of progression included brain 52%, eyes 19%, brain and eyes 12%, and systemic 2%. Patients treated with local ocular therapy did not have a statistically significant decreased risk of failing in the eyes (p ≤ 0.7). Median progression free survival and overall survival for the entire cohort were 18 and 31 months. Conclusion: This is the largest reported series of primary CNS lymphoma (PCNSL) with intraocular involvement. Progression free and overall survival was similar to that reported with PCNSL. Dedicated ocular therapy improved disease control but did not affect overall survival. © 2008 by AAN Enterprises, Inc. |
| Keywords: | adolescent; adult; cancer chemotherapy; cancer survival; controlled study; human tissue; treatment outcome; aged; aged, 80 and over; middle aged; survival rate; retrospective studies; major clinical study; histone deacetylase inhibitor; prednisone; clinical trial; cancer recurrence; doxorubicin; cancer combination chemotherapy; cancer growth; multimodality cancer therapy; cancer radiotherapy; comparative study; primary central nervous system lymphoma; cytarabine; methotrexate; follow up; follow-up studies; antineoplastic agent; cancer diagnosis; t lymphocyte; cyclophosphamide; vincristine; tumor biopsy; medical record review; retrospective study; cancer mortality; ifosfamide; central nervous system tumor; central nervous system neoplasms; b lymphocyte; whole body radiation; multicenter study; lymphoma; research; cooperative behavior; retina; cognitive defect; seizure; headache; choroid; aphasia; brain biopsy; ataxia; hemiparesis; internationality; immunocompetence; cooperation; blurred vision; international cooperation; cerebrospinal fluid cytology; brain lymphoma; visual acuity; behavior change; eye biopsy; intraocular tumor; vitrectomy; eye tumor; eye neoplasms |
| Journal Title: | Neurology |
| Volume: | 71 |
| Issue: | 17 |
| ISSN: | 0028-3878 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2008-01-01 |
| Start Page: | 1355 |
| End Page: | 1360 |
| Language: | English |
| DOI: | 10.1212/01.wnl.0000327672.04729.8c |
| PUBMED: | 18936428 |
| PROVIDER: | scopus |
| PMCID: | PMC4109164 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 23" - "Export Date: 17 November 2011" - "CODEN: NEURA" - "Source: Scopus" |
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