The immunobiology of cancer immunosurveillance and immunoediting Journal Article
| Authors: | Dunn, G. P.; Old, L. J.; Schreiber, R. D. |
| Article Title: | The immunobiology of cancer immunosurveillance and immunoediting |
| Abstract: | The last fifteen years have seen a reemergence of interest in cancer immunosurveillance and a broadening of this concept into one termed cancer immunoediting. The latter, supported by strong experimental data derived from murine tumor models and provocative correlative data obtained by studying human cancer, holds that the immune system not only protects the host against development of primary nonviral cancers but also sculpts tumor immunogenicity. Cancer immunoediting is a process consisting of three phases: elimination (i.e., cancer immunosurveillance), equilibrium, and escape. Herein, we summarize the data supporting the existence of each of the three cancer immunoediting phases. The full understanding of the immunobiology of cancer immunosurveillance and immunoediting will hopefully stimulate development of more effective immunotherapeutic approaches to control and/or eliminate human cancers. |
| Keywords: | antibiotic agent; review; nonhuman; alpha interferon; neoplasms; animals; glycoprotein gp 100; interleukin 2; cancer immunotherapy; immune system; interleukin 10; antineoplastic activity; cytotoxicity; monoclonal antibody; correlation analysis; gamma interferon; recombinant gamma interferon; tumor necrosis factor related apoptosis inducing ligand; tumor cell; immunological adjuvant; melan a; tumor model; monophenol monooxygenase; immunosurveillance; beta interferon; immunocompetent cell; alpha galactosylceramide; cancer immunology; immunologic surveillance; tumor escape; immunity, natural; interferon type ii; immunobiology; humans; human; priority journal |
| Journal Title: | Immunity |
| Volume: | 21 |
| Issue: | 2 |
| ISSN: | 1074-7613 |
| Publisher: | Cell Press |
| Date Published: | 2004-08-01 |
| Start Page: | 137 |
| End Page: | 148 |
| Language: | English |
| DOI: | 10.1016/j.immuni.2004.07.017 |
| PROVIDER: | scopus |
| PUBMED: | 15308095 |
| DOI/URL: | |
| Notes: | Immunity -- Cited By (since 1996):836 -- Export Date: 16 June 2014 -- CODEN: IUNIE -- Source: Scopus |
