Adjuvant therapy following resection for pancreatic adenocarcinoma Journal Article
| Author: | Brennan, M. F. |
| Article Title: | Adjuvant therapy following resection for pancreatic adenocarcinoma |
| Abstract: | Pancreatic adenocarcinoma remains a lethal disease. Approximately 10% to 15% of patients who are able to undergo resection will be alive at 5 years, but most of those will have late recurrence and ultimately die of the disease. Multiple adjuvant treatments have been tested, including extended operations, chemotherapy, radiation therapy, and immunotherapy - the vast majority with minimal, if any, effect. There is a small suggested benefit from adjuvant chemotherapy but little other cause for optimism. At the current time, given the relative failure of standard adjuvant approaches, it is reasonable to suggest that all patients should have tissue harvested for molecular markers and enter into investigative regimens. |
| Keywords: | adult; cancer chemotherapy; cancer survival; treatment outcome; aged; middle aged; survival analysis; surgical technique; survival rate; unclassified drug; clinical trial; review; cisplatin; fluorouracil; interferon; cancer combination chemotherapy; multimodality cancer therapy; gemcitabine; cancer adjuvant therapy; pancreas resection; radiation dose; chemotherapy, adjuvant; pancreatic neoplasms; radiotherapy, adjuvant; cytarabine; lymph node metastasis; neoplasm staging; pancreaticoduodenectomy; adenocarcinoma; cancer immunotherapy; antineoplastic combined chemotherapy protocols; radiotherapy dosage; practice guideline; risk assessment; survival time; statistical significance; immune response; folinic acid; mitoxantrone; pancreas adenocarcinoma; pancreatectomy; tumor vaccine; marimastat; pancreas islet cell carcinoma; matrix metalloproteinase inhibitor; duodenum cancer; caffeine; oncophage; humans; prognosis; human; male; female; hsppc 96 tumor vaccine |
| Journal Title: | Surgical Oncology Clinics of North America |
| Volume: | 13 |
| Issue: | 4 |
| ISSN: | 1055-3207 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2004-10-01 |
| Start Page: | 555 |
| End Page: | 566 |
| Language: | English |
| DOI: | 10.1016/j.soc.2004.06.008 |
| PROVIDER: | scopus |
| PUBMED: | 15350934 |
| DOI/URL: | |
| Notes: | Surg. Oncol. Clin. North Am. -- Cited By (since 1996):21 -- Export Date: 16 June 2014 -- CODEN: SOCAF -- Source: Scopus |
