Developmental neurobiology and the origin of brain tumors Journal Article
| Authors: | Shih, A. H.; Holland, E. C. |
| Article Title: | Developmental neurobiology and the origin of brain tumors |
| Abstract: | Our knowledge of the causes of brain tumors has steadily increased and is leading to a refined understanding of the signaling pathways that may be essential for tumor formation. At the same time, we are gaining insights into the developmental processes that regulate the formation of the diverse range of cell types in the normal brain. Interestingly, many of these pathways seem to overlap and suggest common mechanisms regulating tumor formation and cellular development. This overlap may also inform us about the nature of the cell of origin for different types of brain tumors. By appreciating the inter-relationship between tumor formation and development, we may be able to design new therapeutics targeting tumors for new modes of treatment. © 2004 Kluwer Academic Publishers. |
| Keywords: | signal transduction; epidermal growth factor; platelet derived growth factor; somatomedin; controlled study; clinical feature; review; nonhuman; treatment planning; brain tumor; brain neoplasms; animals; cell cycle; cell maturation; signaling; bone morphogenetic protein; sonic hedgehog protein; cell type; stem cell; cell transformation, neoplastic; dna modification; brain; brain development; granule cell; interleukin 6; stem cells; cycline; tumor growth; fibroblast growth factor; progenitor; brain nerve cell; neurobiology; humans; human; developmental neurobiology; ciliary neurotrophic factor |
| Journal Title: | Journal of Neuro-Oncology |
| Volume: | 70 |
| Issue: | 2 |
| ISSN: | 0167-594X |
| Publisher: | Springer |
| Date Published: | 2004-11-01 |
| Start Page: | 125 |
| End Page: | 136 |
| Language: | English |
| DOI: | 10.1007/s11060-004-2746-3 |
| PROVIDER: | scopus |
| PUBMED: | 15674474 |
| DOI/URL: | |
| Notes: | J. Neuro-Oncol. -- Cited By (since 1996):24 -- Export Date: 16 June 2014 -- CODEN: JNODD -- Source: Scopus |
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