G1 cell-cycle control and cancer Journal Article
| Author: | Massagué, J. |
| Article Title: | G1 cell-cycle control and cancer |
| Abstract: | Before replicating DNA during their reproductive cycle, our cells enter a phase called G1 during which they interpret a flood of signals that influence cell division and cell fate. Mistakes in this process lead to cancer. An increasingly complex and coherent view of G1 signalling networks, which coordinate cell growth, proliferation, stress management and survival, is helping to define the roots of malignancies and shows promise for the development of better cancer therapies. |
| Keywords: | signal transduction; human cell; review; cancer growth; dna replication; neoplasms; cell proliferation; animals; dna damage; cell survival; cell cycle; cell division; cell function; protein bcl 2; cell growth; smad protein; cell fate; cell differentiation; protein bcl xl; stem cell; tumors; cycline; stress management; phosphotransferase; signal processing; cell cycle g1 phase; g1 phase; cytostasis; cells; target of rapamycin kinase; cancer; humans; human; priority journal; reproductive cycle; signalling networks |
| Journal Title: | Nature |
| Volume: | 432 |
| Issue: | 7015 |
| ISSN: | 0028-0836 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2004-11-01 |
| Start Page: | 298 |
| End Page: | 306 |
| Language: | English |
| DOI: | 10.1038/nature03094 |
| PROVIDER: | scopus |
| PUBMED: | 15549091 |
| DOI/URL: | |
| Notes: | Nature -- Cited By (since 1996):485 -- Export Date: 16 June 2014 -- CODEN: NATUA -- Source: Scopus |
