Global mapping of the yeast genetic interaction network Journal Article
| Authors: | Tong, A. H. Y.; Lesage, G.; Bader, G. D.; Ding, H.; Xu, H.; Xin, X.; Young, J.; Berriz, G. F.; Brost, R. L.; Chang, M.; Chen, Y.; Cheng, X.; Chua, G.; Friesen, H.; Goldberg, D. S.; Haynes, J.; Humphries, C.; He, G.; Hussein, S.; Ke, L.; Krogan, N.; Li, Z.; Levinson, J. N.; Lu, H.; Ménard, P.; Munyana, C.; Parsons, A. B.; Ryan, O.; Tonikian, R.; Roberts, T.; Sdicu, A. M.; Shapiro, J.; Sheikh, B.; Suter, B.; Wong, S. L.; Zhang, L. V.; Zhu, H.; Burd, C. G.; Munro, S.; Sander, C.; Rine, J.; Greenblatt, J.; Peter, M.; Bretscher, A.; Bell, G.; Roth, F. P.; Brown, G. W.; Andrews, B.; Bussey, H.; Boone, C. |
| Article Title: | Global mapping of the yeast genetic interaction network |
| Abstract: | A genetic interaction network containing ∼1000 genes and ∼4000 interactions was mapped by crossing mutations in 132 different query genes into a set of ∼4700 viable gene yeast deletion mutants and scoring the double mutant progeny for fitness defects. Network connectivity was predictive of function because interactions often occurred among functionally related genes, and similar patterns of interactions tended to identify components of the same pathway. The genetic network exhibited dense local neighborhoods; therefore, the position of a gene on a partially mapped network is predictive of other genetic interactions. Because digenic interactions are common in yeast, similar networks may underlie the complex genetics associated with inherited phenotypes in other organisms. |
| Keywords: | gene cluster; gene deletion; mutation; nonhuman; phenotype; genes; computational biology; genotype; gene function; prediction; gene mapping; amino acid sequence; molecular sequence data; saccharomyces cerevisiae; cystic fibrosis; molecular interaction; yeast; saccharomyces cerevisiae proteins; polymorphism, genetic; mutagenesis; fungal gene; retinitis pigmentosa; mutants; defects; genes, fungal; genes, essential; multifactorial inheritance; genetic diseases, inborn; humans; priority journal; article; genetic interaction network |
| Journal Title: | Science |
| Volume: | 303 |
| Issue: | 5659 |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Date Published: | 2004-02-06 |
| Start Page: | 808 |
| End Page: | 813 |
| Language: | English |
| DOI: | 10.1126/science.1091317 |
| PROVIDER: | scopus |
| PUBMED: | 14764870 |
| DOI/URL: | |
| Notes: | Science -- Cited By (since 1996):1149 -- Export Date: 16 June 2014 -- CODEN: SCIEA -- Source: Scopus |
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