Functional genomics and proteomics: Charting a multidimensional map of the yeast cell Journal Article
| Authors: | Bader, G. D.; Heilbut, A.; Andrews, B.; Tyers, M.; Hughes, T.; Boone, C. |
| Article Title: | Functional genomics and proteomics: Charting a multidimensional map of the yeast cell |
| Abstract: | The challenge of large-scale functional genomics projects is to build a comprehensive map of the cell including genome sequence and gene expression data, information on protein localization, structure, function and expression, post-translational modifications, molecular and genetic interactions and phenotypic descriptions. Some of this broad set of functional genomics data has been already assembled for the budding yeast. Even though molecular cartography of the yeast cell is still far from comprehensive, functional genomics has begun to forge connections between disparate cellular events and to foster numerous hypotheses. Here we review several different genomics and proteomics technologies and describe bioinformatics methods for exploring these data to make new discoveries. |
| Keywords: | signal transduction; protein expression; gene mutation; gene sequence; sequence analysis; gene deletion; review; validation process; polymerase chain reaction; protein function; protein localization; protein analysis; phenotype; cytology; gene expression; gene expression profiling; computational biology; protein protein interaction; analytic method; genetic transcription; biotechnology; proteomics; nuclear proteins; rna; gene mapping; genome analysis; protein processing; transcription regulation; saccharomyces cerevisiae; quantitative analysis; gene interaction; data analysis; genomics; crystal structure; dna microarray; molecular interaction; saccharomyces cerevisiae proteins; saccharomycetales; protein structure; structure analysis; bioinformatics; genetic code; fungi; yeast cell; gene expression regulation, fungal; gene structure; chromosome mapping; protein dna interaction; genetic database; gene technology; cross linking; fungal genetics; priority journal; myxogastria |
| Journal Title: | Trends in Cell Biology |
| Volume: | 13 |
| Issue: | 7 |
| ISSN: | 0962-8924 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2003-07-01 |
| Start Page: | 344 |
| End Page: | 356 |
| Language: | English |
| DOI: | 10.1016/s0962-8924(03)00127-2 |
| PUBMED: | 12837605 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 25 September 2014 -- Source: Scopus |
