Gene expression profiling of tamoxifen-associated uterine cancers: Evidence for two molecular classes of endometrial carcinoma Journal Article

  

Authors:	Ferguson, S. E.; Olshen, A. B.; Viale, A.; Awtrey, C. S.; Barakat, R. R.; Boyd, J.
Article Title:	Gene expression profiling of tamoxifen-associated uterine cancers: Evidence for two molecular classes of endometrial carcinoma
Abstract:	Objective. Endometrial cancers associated with tamoxifen exposure potentially represent a unique resource for investigating the molecular mechanisms of estrogen-induced tumorigenesis. The purpose of this study was to test the hypothesis that tamoxifen-associated endometrial carcinomas have a distinct gene expression profile compared to matched cases not associated with this exposure. Methods. Microarray-based expression profiling was performed on a series of tamoxifen-associated (N = 10) and matched sporadic cases (N = 29) of endometrial carcinoma. Results. Supervised class comparison revealed no statistically significant difference between the two groups (P = 0.48). However, unsupervised hierarchical clustering of the entire sample of tumors revealed two groups with extremely diverse molecular profiles that were independent of tamoxifen exposure. Of recognized clinicopathological factors, histologic grade correlated best with these two molecular classes. Conclusions. These data suggest that the molecular profile of tamoxifen-associated endometrial cancers is not different from that of endometrial carcinomas generally, and further, that there exist two highly distinct molecular subtypes of endometrial carcinoma. © 2003 Elsevier Inc. All rights reserved.
Keywords:	adult; clinical article; controlled study; human tissue; aged; middle aged; case-control studies; clinical feature; histopathology; comparative study; endometrium carcinoma; endometrial neoplasms; breast cancer; gene expression profiling; molecular dynamics; carcinogenesis; cancer genetics; correlation analysis; statistical significance; oligonucleotide array sequence analysis; tamoxifen; dna microarray; antineoplastic agents, hormonal; cancer classification; uterus cancer; endometrial carcinoma; gene expression profile; humans; human; female; priority journal; article
Journal Title:	Gynecologic Oncology
Volume:	92
Issue:	2
ISSN:	0090-8258
Publisher:	Elsevier Inc.
Date Published:	2004-02-01
Start Page:	719
End Page:	725
Language:	English
DOI:	10.1016/j.ygyno.2003.10.038
PROVIDER:	scopus
PUBMED:	14766275
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-0842267344&partnerID=40&md5=174c17d60008e4c7e3d4a50bac316796
Notes:	Gynecol. Oncol. -- Cited By (since 1996):31 -- Export Date: 16 June 2014 -- CODEN: GYNOA -- Source: Scopus

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