Overexpression of E2F-1 in lung and liver metastases of human colon cancer is associated with gene amplification Journal Article
| Authors: | Iwamoto, M.; Banerjee, D.; Menon, L. G.; Jurkiewicz, A.; Rao, P. H.; Kemeny, N. E.; Fong, Y.; Jhanwar, S. C.; Gorlick, R.; Bertino, J. R. |
| Article Title: | Overexpression of E2F-1 in lung and liver metastases of human colon cancer is associated with gene amplification |
| Abstract: | We have shown previously that metastatic tumors of human colorectal cancer in lung as compared to liver have high levels of thymidylate synthase (TS) mRNA expression that correlated with high levels of E2F-1 mRNA expression. We now report that Comparative Genomic Hybridization (CGH) and DNA PCR analyses of lung and liver metastases of human colon cancer show frequent gains in the region of chromosome 20q and have an increase in gene copy number of E2F-1. In as much as TS is transcriptionally regulated by E2F-1, these results provide an explanation for the high levels of TS mRNA noted in some tumor samples. ©2004 Landes Bioscience. |
| Keywords: | controlled study; human tissue; dna binding protein; major clinical study; genetics; dna-binding proteins; liver neoplasms; polymerase chain reaction; colorectal cancer; adenocarcinoma; cell cycle protein; cell cycle proteins; gene overexpression; metastasis; gene amplification; lung neoplasms; colonic neoplasms; transcription factor; genetic transcription; transcription, genetic; pathology; transcription factors; lung tumor; gene number; liver metastasis; lung metastasis; biosynthesis; correlation analysis; dna; transcription regulation; messenger rna; colon cancer; colon tumor; transcription factor e2f; liver tumor; dna, neoplasm; liver enzyme; metastases; thymidylate synthase; comparative genomic hybridization; dna determination; transcription factor e2f1; chromosome 20; chromosomes, human, pair 20; e2f1 transcription factor; e2f transcription factors; humans; human; article; 20q; e2f-1 gene amplification; e2f1 protein, human |
| Journal Title: | Cancer Biology and Therapy |
| Volume: | 3 |
| Issue: | 4 |
| ISSN: | 1538-4047 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2004-04-01 |
| Start Page: | 395 |
| End Page: | 399 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 14726656 |
| DOI: | 10.4161/cbt.3.4.733 |
| DOI/URL: | |
| Notes: | Cancer Biol. Ther. -- Cited By (since 1996):28 -- Export Date: 16 June 2014 -- Source: Scopus |
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